Anaesthesia Clinical Trial
Official title:
POPULAR: POst-operative PULmonary Complications After Use of Muscle Relaxants in Europe - A European Prospective Multicenter Observational Study
International multicenter observational study of a random-sample cohort of patients
undergoing any in-hospital surgical procedure under general or regional anaesthesia during a
continued 14-day period of recruitment.
Primary hypothesis of this study is that the use of muscle relaxants, their reversal agents,
or neuromuscular monitoring increases the incidence of postoperative pulmonary
complications. The secondary hypothesis is that the use of muscle relaxants increases
in-hospital mortality.
Overall postoperative mortality for patients undergoing non-cardiac surgery in Europe is 4%
(EUSOS study). Postoperative pulmonary complications are a major factor, which increase
patient morbidity and mortality (PERISCOPE study). This study is designed to evaluate the
effects of management of neuromuscular blockade on postoperative pulmonary complications in
a general unrestricted anaesthetized population across Europe. The investigation will be a
continuation of the European EUSOS and PERISCOPE studies. Based on a well-recognised body of
surrogate data, it is hypothesized that incorrect approaches to the use, monitoring, and
reversal of muscle relaxants will increase the incidence of in-hospital postoperative
pulmonary complications and prolong hospital stay.
The investigators will not modify a participating centre's customary management of patients.
Patients with postoperative pulmonary complications will be identified by postoperative
assessment and consulting medical records for events that fulfil the definition of
postoperative pulmonary complications.
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Observational Model: Cohort, Time Perspective: Prospective
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