Anaerobic Performance Clinical Trial
Official title:
Psychophysical Aspects of Maximal Anaerobic Performance
During anaerobic exercise, the metabolic pathway of glycolysis is used in order to produces
high-energy compounds adenosine triphosphate (ATP).The level of lactic acid in the blood is
a marker to the increased protons concentration and acidosis.nevertheless, the increased
level of protons in addition to the release of bradykinin causes pain during the exercise
that limited the subject's performance. Therefore, it is assumed that the individual pain
sensitivity might determine the subject's performance.
Aims: To investigate the role of the DNIC efficiency in prediction of anaerobic performance
in humans (2) to study the role of peripheral pro-nociceptive processing in mediating pain
during anaerobic exercise and its contribution to the subjects' performance (3) to assess
the function of pain-related psychological factors in anaerobic performance.
To the best of our knowledge, no study has investigated the balance between the endogenous
anti-nociceptive properties of the individual and the anaerobic-evoke pro-nociceptive
activity in determining the maximal performance during anaerobic exercise. Moreover, the
interaction between psychological factors and pro- and anti- nociceptive processes that are
operated during anaerobic exercise, need to be investigated.
Methods: Forty healthy men and women, between the ages of 18-40 will be involved in the
study. Each participant will complete 3 psychological questionnaires regarding their
personality traits: Pain Catastrophizing Scale (PCS), State-Trait Anxiety Inventory and
Perceived Stress Questionnaire. Pain psychophysics tests will be used for evaluating the
individual pain perception, prior and subsequent to the anaerobic exercise: (1) DNIC will be
tested using a paradigm of two remote noxious stimuli with one, the 'conditioning stimulus'
(immersing the hand in tub containing 8°c water), inhibiting the other, the 'test pain'
(pressure pain threshold) in order to assess the endogenous analgesia (EA) efficiency (2)
heat and pressure pain thresholds, and (3) temporal summation of painful heat and mechanical
stimuli that reflect the neuroplasticity of the central nervous system following peripheral
noxious stimulation. In addition, Anaerobic performance will be evaluated during Wingate
test,and blood lactate will be measured. Gene related pain ill be tested using saliva
samples .
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening