Amyotrophic Lateral Sclerosis Clinical Trial
Official title:
Autologous Purified Bone-Marrow-Derived Stem Cell Therapy for Motor Neuron Disease
Herein, the investigators study the safety and efficacy of transplanting purified autologous bone marrow-derived stem cells transplanted via the intrathecal route by interventional radiology and the intravenous route.
A motor neuron disease (MND) is any of several neurological disorders that selectively affect
motor neurons, the cells that control voluntary muscles of the body. They include amyotrophic
lateral sclerosis (ALS), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA),
progressive bulbar palsy (PBP) and pseudobulbar palsy; spinal muscular atrophies are also
sometimes included in the group.They are neurodegenerative diseases that cause increasing
disability and eventually, death.
In spite of intensive research, motor neuron diseases (MNDs) are still incurable. Some of the
key factors in this failure to find a cure have been the lack of human cell-based disease
models for molecular analysis and drug screening and the difficulty of obtaining homogeneous
populations of specific cell types for clinical applications. Stem cell biology has the
potential to transform our understanding of disease processes and to revolutionize our
approach to develop novel therapies for MNDs.
In this study, the investigators suggest a protocol for the treatment of MND by
transplantation of purified autologous bone marrow-derived stem cells via the intrathecal and
intravenous route.
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