Amyotrophic Lateral Sclerosis Clinical Trial
Official title:
Ultrasound Markers for the Diagnosis, Disease Progression and Prognosis of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurological disease.
Nonspecific symptoms lead to a delay in the diagnosis, only confirmed by the
electrophysiologic study.
Objectives.
1. To establish the diagnostic value of ultrasonography in ALS.
2. To evaluate the rate of muscle and nerve degeneration by ultrasonography in patients
with ALS.
3. To check the relationship between ultrasound, clinical variables and functional tests
in patients with ALS.
Methods. A longitudinal observational study in a consecutive sample of patients diagnosed
with ALS will be realized. All the patients will be examined 3 times during 6 months and
capabilities associated with ALS and muscle strength will be assessed. Bilateral and cross
sectional ultrasonography of several muscles and also median and tibial nerves will be
performed. All the images will be processed and analyzed for obtaining morphometric
variables (muscle thickness and nerve area) and textural ones (echogenic variation, entropy,
homogeneity, textural contrast and correlation). Frequency of twitches will be also
recorded. After longitudinal study, a survival study will be performed in relation to
functional and sonographic variables.
n/a
Observational Model: Case Control, Time Perspective: Retrospective
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