Developing a Discrimination Model to Diagnose ALS

Status Completed

Clinical Trial Summary

To combine several brain imaging techniques to develop a new diagnostic test to help with earlier diagnosis of amyotrophic lateral sclerosis.

Clinical Trial Description

Early diagnosis and lack of understanding of the pathophysiology of ALS remain a significant obstacle to making a timely intervention to help patients suffering from this fatal disease. We envision a future in which neuroimaging techniques will be a critical tool in the diagnostic work-up of ALS. Advanced neuroimaging techniques offer great potential in identifying central nervous system metabolite and cellular alterations in ALS. We propose an innovative approach to combine complementary advanced MRI techniques to interrogate brain chemistry (MRS), brain microstructure (DTI) and brain function (fcMRI) and develop a clinically relevant discriminatory disease model. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01995903
Study type	Interventional
Source	University of Michigan
Contact
Status	Completed
Phase	N/A
Start date	April 2012
Completion date	October 2015

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