Amyotrophic Lateral Sclerosis Clinical Trial
Official title:
Open Multicenter Study of Lithium in Patients With Amyotrophic Lateral Sclerosis LISLA
The purpose of the study is to determine whether lithium is safe and effective in the treatment of ALS
Daily doses of lithium, have been found to delay progression of amyotrophic lateral
sclerosis (ALS) in a 15-month study of 44 patients with ALS. At the end of the trial, about
30 percent of the patients that took riluzole had died, while all those receiving riluzole
plus lithium had survived. the lithium group had slower progression as measure by a test of
breathing (FVC) and strength.
This study will determine whether lithium in combination with riluzole delay progression of
patients with amyotrophic lateral sclerosis disease in comparison of an historical cohort of
ALS patients treated with riluzole alone.
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Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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