Amyotrophic Lateral Sclerosis Clinical Trial
Official title:
A Multicenter Study for the Validation of ALS Biomarkers
The purpose of this study is to collect 650 blood and 300 cerebrospinal fluid (CSF) samples
from people with amyotrophic lateral sclerosis (ALS), pure lower or upper motor neuron
diseases, as well as other neurodegenerative diseases and from people with no neurological
disorder. Through comparison of these samples, the researchers hope to learn more about the
underlying cause of ALS, as well as find unique biological markers, which could be used to
diagnose ALS and monitor disease progression.
Additionally, up to 600 blood samples will be collected for a sub-study for DNA analysis.
Studying components of the blood, such as DNA, may help us understand what happens when
genes function abnormally and how it might be related to disease.
Researchers tested what changes happen in volunteers with ALS that can be seen in the blood and what changes are unique to ALS and are different from those found in healthy volunteers and volunteers with neurological diseases other than ALS. These changes are called biomarkers. Biomarkers for ALS have been found in blood collected in earlier phases of this study. Biomarkers are non-genetic elements in your blood that may help to make diagnosing ALS easier. In the next phase, comparison of these changes in the blood of volunteers with ALS and without ALS will be used to confirm these biomarkers and to develop a tool to diagnose and monitor progression of ALS. ;
Observational Model: Case Control, Time Perspective: Prospective
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