Carpal Tunnel Release With Risk Factors for Amyloidosis

Status Recruiting

Clinical Trial Summary

Bilateral carpal tunnel syndrome has been demonstrated in previous literature to be a warning sign for potential amyloidosis. One study has been performed in which patients with bilateral carpal tunnel syndrome underwent tissue biopsy (either tendon sheath or transverse carpal ligament) at the time of carpal tunnel release to determine the strength of association as well as most common subtypes. However, no study has been done demonstrating whether or not patients with amyloid-positive carpal tunnel biopsy would benefit from an early referral to cardiology for a work-up of potential cardiac amyloidosis. In our study, patients with bilateral carpal tunnel symptoms who are indicated for carpal tunnel release would be identified in clinic and undergo biopsy for congo red staining at the time of surgery. All patients with positive biopsy results would be referred to cardiology. Outcomes would include the rate of amyloid positivity, common subtypes, and echocardiographic findings after cardiac referral.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Amyloidosis

Clinical Trial Details

NCT number	NCT05793320
Study type	Interventional
Source	Henry Ford Health System
Contact	Logan Hansen, MD
Phone	313-916-2600
Email	lhansen2@hfhs.org
Status	Recruiting
Phase	N/A
Start date	August 3, 2023
Completion date	December 3, 2024

View Details

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