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Identification of Clinically Significant Markers of ATTRv in Pre-symptomatic Mutation Carriers.

Amyloidosis Clinical Trial

Official title:
Identification of Clinically Significant Markers of Hereditary Transthyretin Amyloidosis (TTR) in Pre-symptomatic Mutation Carriers: a Prospective Longitudinal Multicentre Study

Clinical Trial Summary

The objective of this prospective observational study is to periodically monitor pre-symptomatic subjects carrying a mutation of Transthyretin (TTR), identified in the context of a family screening of affected proband, through instrumental methods and clinical scales in order to identify the first signs of clinically significant organ involvement by the disease. Healthy asymptomatic carriers will be subjected to regular monitoring through clinical evaluations and instrumental investigations defined by the consensus group (Conceicao et al.) in order to validate the criteria defined by this group to define the onset of the disease. A subgroup of carriers with scales and instrumental tests negative for damage to the peripheral nervous system or cardiac, but with subjective symptoms compatible with the disease, will be subjected to further instrumental tests not indicated by consent.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05754099
Study type Observational
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Marco Luigetti, MD
Phone 0630154303
Email marco.luigetti@policlinicogemelli.it
Status Recruiting
Phase
Start date March 1, 2022
Completion date November 30, 2024
View Details
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