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Ultrasound Therapy In Cardiac Amyloidosis — UTICA  

Amyloidosis Cardiac Clinical Trial

Official title:
Ultrasound Therapy In Cardiac Amyloidosis

Clinical Trial Summary

This is a prospective pilot clinical study of subjects with cardiac amyloidosis and control subjects without amyloidosis where we plan to evaluate changes in myocardial blood flow, systolic and diastolic function before and after sonotherapy.

Clinical Trial Description

70 subjects will be enrolled in this study in 3 study groups: A) 30 subjects with light chain cardiac amyloidosis B) 30 subjects with transthyretin cardiac amyloidosis and C) 10 subjects without amyloidosis. All subjects will undergo rest 2D echocardiography, rest N-13 ammonia or rubidium-82 perfusion PET, Definity infusion with high mechanical index (MI) imaging defined as sonotherapy in this study protocol. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04667494
Study type Interventional
Source Brigham and Women's Hospital
Contact Sharmila Dorbala, MD
Phone 617-732-6290
Email sdorbala@bwh.harvard.edu
Status Recruiting
Phase Phase 4
Start date August 31, 2023
Completion date April 30, 2027
View Details
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