Clinical Trials Logo
  1. Home
  2. Amputation, Traumatic
  3. NCT03241719

Novel Strategies to Improve Immunomodulation and Non-invasive Clinical Monitoring in VCA

Amputation, Traumatic Clinical Trial

Official title:
Novel Strategies to Improve Immunomodulation and Non-invasive Clinical Monitoring in Vascularized Composite Allotransplantation

Clinical Trial Summary

The objective of this study is to develop a feasible and safe regimen for minimization of immune suppression in recipients of vascularized composite allotransplants (VCA) using a daily dose of recombinant IL-2. In order to achieve this aim, this trial will: 1. Perform VCA in 5 eligible subjects; 2. Administer recombinant IL-2 at a low-dose to promote the expansion and function of regulatory T cells in subjects who received VCA; and 3. Minimize immune suppression to tacrolimus single therapy in subjects who received VCA and recombinant IL-2. This trial will also investigate if it is possible to predict immune rejection in VCA using blood and tissue samples from recipients of VCA. Lastly, this trial will develop non-invasive technologies to monitor for VCA rejection. These technologies will involve magnetic resonance imaging. Multi-contrast ultra-high resolution MR imaging (MRI) with serial direct planimetry will be performed in recipients of VCA.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03241719
Study type Interventional
Source Brigham and Women's Hospital
Contact
Status Terminated
Phase Early Phase 1
Start date October 17, 2017
Completion date July 21, 2021
View Details
See also
  Status Clinical Trial Phase
Completed NCT04070105 - No Power Bionic Lower Extremity Prosthesis N/A
Completed NCT03317600 - Postamputation Pain: Peripheral Mechanisms N/A
Not yet recruiting NCT02934074 - Relationship Between Gait Variability and Sensation N/A
Completed NCT02318979 - What is the Optimal Stiffness and Height of a Running-specific Prosthesis? N/A
Completed NCT03412656 - Assessing Force Feedback With the SoftHand Pro N/A
Completed NCT04262297 - Rectus Femoris Thickness Measurement in Unilateral Transtibial Amputated Prosthesis Users
Enrolling by invitation NCT02956603 - Studying Electromyographic Activity in Patients With Upper Limb Amputations N/A
Recruiting NCT05297266 - Early Discovery of Ischemia After Replantation Surgery of the Extremities N/A
Enrolling by invitation NCT02601456 - Changes in Trans Tibial Amputee Running Asymmetry During Prolonged Effort N/A
Terminated NCT02328703 - Reiki for the Management of Neuropathic Pain N/A
Completed NCT01901081 - Feasibility of Implantable Myoelectric Sensors to Control Upper Limb Prostheses N/A
Recruiting NCT05827744 - The Relationship Between Thicknesses and Isokinetic Strength of Hip Flexor and Extensor Muscles
Recruiting NCT06433648 - Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait N/A
Not yet recruiting NCT05786690 - The Effect of Microprocessor Controlled Prostheses on Walking Pattern and Energy Consumption
Completed NCT05188599 - Isokinetic Parameters and the Amputee Mobility Predictor Scale
Recruiting NCT02395497 - Human Penile Allotransplantation Phase 2/Phase 3
Recruiting NCT04725461 - Low Cost Socket for Lower Limb Amputees N/A
Recruiting NCT03400345 - Human Upper Extremity Allotransplantation: F/U Protocol
Completed NCT02828982 - Determining the Potential Benefit of Powered Prostheses N/A
Active, not recruiting NCT02487966 - Optimizing Rehabilitation for Phantom Limb Pain Using Mirror Therapy and Transcranial Direct Current Stimulation (tDCS) N/A