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Low-dose Venetoclax and Azacitidine as Front-line Therapy in Newly Diagnosed AML

AML Clinical Trial

Official title:
Efficacy and Safety of Ambulatory Low-dose Venetoclax and Azacitidne as First Line Therapy in Newly Diagnosed AML: a Pilot Study

Clinical Trial Summary

Venetoclax plus azacitidine are effective in treating newly diagnosed AML in patients who cannot recieve intensive chemotherapy. However there is no clinical data rewarding the efficacy and safety of low-dose venetoclax and azacitidine as first-line therapy.

Clinical Trial Description

Venetoclax plus azacitidine are effective in treating newly diagnosed AML in patients who cannot recieve intensive chemotherapy. However there is no clinical data rewarding the efficacy and safety of low-dose venetoclax and azacitidine as first-line therapy. This phase 2 clinical trial will explore the efficacy and safety of low-dose venetoclax (100mg /day/21 days) and a fixed dose of azacitidine (75mg/m2, maximun dose 100mg, SC for seven consecutive days) for a maximun of two cycles. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05048615
Study type Interventional
Source Hospital Universitario Dr. Jose E. Gonzalez
Contact
Status Completed
Phase Phase 2
Start date July 26, 2021
Completion date January 20, 2023
View Details
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