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NCT00687414 Clinical Trial

Evaluation of Formin Gene Status and Expression in Myeloproliferative and Myelodysplastic Disorders

AML Clinical Trial

Official title:
Evaluation of Formin Gene Status and Expression in Myeloproliferative and Myelodysplastic Disorders

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00687414
Other study ID # 2008-054
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 2008
Est. completion date January 2010

Study information
Verified date July 2023
Source Spectrum Health Hospitals
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Aim of the study is to analyze the expression of genes and sequences encoding the human mammalian diaphanous (mDia) related formin proteins to test the hypothesis that defects in the mDia expression or function might drive the pathophysiology of myelodysplastic syndrome, acute myeloid leukemia and other myeloproliferative diseases.

Description:

Leukocytes and myeloid lineage cells from these specimens will be assayed for expression of DRF genes using standard molecular biological approaches to measure mRNA levels. Extracted DNA will be analyzed for mutations that affect expressions or function using direct sequencing techniques. Alternatively, expression of DRF gene products (mDia proteins) will be assessed using specific antibodies and flow cytometry. Molecular findings resulting from these assays will be correlated with clinical information recorded in specimen logbook.

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date January 2010
Est. primary completion date December 2009
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - 18 and over - Male - Female - Diagnosed with MDS, MPD and AML Exclusion Criteria: - Under the age of 18 - Received bone marrow transplant Control Group Criteria: inclusion: - healthy men and women - = 55 years of age exclusion: - history of hematological condition - history of cancer

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States St Mary's Health Care Grand Rapids Michigan
United States Van Andel Research Institute Grand Rapids Michigan

Sponsors (3)
Lead Sponsor Collaborator
Spectrum Health Hospitals Community Foundation for Southeast Michigan (JP McCarthy Fund), Van Andel Research Institute

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary to determine if defective DRF1 expression or mDia1 function may contribute to myeloid malignancies and point to mDia1 as an attractive therapeutic target in MDS and MPS within a year
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