Development of Multimodal Fusion Warning System and Non-invasive Techniques for Early Alzheimer's Detection.

Alzheimer's Disease Clinical Trial

Official title: The Development of Early-stage Alzheimer's Disease Multimodal Fusion Warning System and Non-invasive Neurostimulation Techniques.

Status Recruiting

Clinical Trial Summary

Developing and validating an early digitalized recognition device and multimodal warning model for Alzheimer's disease, and establishing a precision transcranial ultrasound stimulation intervention system.

Clinical Trial Description

1. Establishment of early digitalized recognition devices and multimodal warning models for AD: Participants undergo clinical assessments, and if they meet the inclusion criteria, their gender, age, MMSE, MoCA, CDR, GDS scores, as well as EEG ERP and MR data are collected. Eye-tracking analysis based on human-computer interaction perception technology, limb movement detection, and laser radar depth sensor fusion cognitive assessment are also performed simultaneously. After enrollment, follow-up assessments using scales (MMSE, MoCA, CDR, GDS, ADAS-cog, etc.) are conducted every six months, and EEG ERP and MR data are collected annually.

2. Construction of a precision transcranial ultrasound stimulation intervention system:

Participants were randomly divided into true stimulation group and false stimulation group: true/false stimulation for 2 weeks, washout for 2 weeks, false/true stimulation for 2 weeks. After treatment, behavioral scale assessment, EEG ERP and multimodal MRI were performed to evaluate the therapeutic effect. ;

Related Conditions & MeSH terms

• Alzheimer Disease
• Alzheimer's Disease

• NCT number: NCT05978830
• Study type: Interventional
• Source: First Affiliated Hospital of Zhejiang University
• Contact: Yi Ling, Dr
• Phone: 15168236137
• Email: 12118458@zju.edu.cn
• Status: Recruiting
• Phase: N/A
• Start date: March 1, 2022
• Completion date: December 30, 2024