Autobiographical Memory

Alzheimer's Disease Clinical Trial

— EMAM  

Official title:

Eye Movement During Autobiographical Memory in Alzheimer's Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04584138
• Other study ID #: RC20_0322
• Status: Completed
• Start date: April 15, 2021
• Est. completion date: November 25, 2022

Study information

• Verified date: March 2023
• Source: Nantes University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study aims at the assessment of eye movement during autobiographical retrieval (i.e., retrieval of personal memories) in patients with Alzheimer's Disease.

Description:

There is an increased interest in the study of eye movements during the retrieval of autobiographical memories and recent research has demonstrated how retrieval of autobiographical memory can activate eye movement. This research has been however mainly concerned with young adults and, until now, little is known about the relationship between eye movement and autobiographical memory in patients with Alzheimer's Disease. The aim of the current study is therefore to evaluate eye movements during the retrieval of autobiographical memories in patients with Alzheimer's Disease.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 54
• Est. completion date: November 25, 2022
• Est. primary completion date: November 25, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria :

• Diagnosis of Alzheimer's Disease at the mild stage

Exclusion Criteria :

• Neurological/psychiatric disorders (other than Alzheimer's Disease)

Related Conditions & MeSH terms

• Alzheimer Disease
• Alzheimer's Disease
• Autobiographical Memory
• Eye Movement
• Memory

Intervention

Behavioral:
• Study of eye movements
The assessment of eye movement during autobiographical retrieval (i.e., retrieval of personal memories) in patients with Alzheimer's Disease.

Locations

Country	Name	City	State
France	CHU de Nantes	Nantes

Sponsors (1)

Lead Sponsor	Collaborator
Nantes University Hospital

Country where clinical trial is conducted

France, 

References & Publications (1)

El Haj M, M J Janssen S, Gallouj K, Lenoble Q. Autobiographical Memory Increases Pupil Dilation. Transl Neurosci. 2019 Dec 19;10:280-287. doi: 10.1515/tnsci-2019-0044. eCollection 2019. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of fixations and saccades	Number	Four weeks (from assessment till analysis)
Primary	Duration of fixations and saccades	Duration in milliseconds	Four weeks (from assessment till analysis)
Secondary	Pupil size	In millimeter	Four weeks (from assessment till analysis)

External Links

•   Autobiographical Memory Increases Pupil Dilation