Alzheimer's Disease Clinical Trial
Official title:
Omega 3 PUFA for the Vascular Component of Age-related Cognitive Decline
Brain scans can help identify changes that appear to increase risk for cognitive decline and dementia. Some of these brain changes are thought to reflect actual damage to the small blood vessels that support normal brain function. This clinical trial will determine whether an omega 3 polyunsaturated fatty acid (PUFA) therapy can promote brain health by supporting the small blood vessels in the brain over 3 years in older adults at high risk for cognitive decline and dementia of Alzheimer's type.
The main objective of this study is to determine if omega 3 PUFA can slow the accumulation of
brain MRI derived white matter hyper-intensities (WMH) over 3 years in a population at risk
for dementia. This trial is designed to collect preliminary data into the mechanism by which
PUFA therapy operates on the brain with special attention to the vascular components.
The randomized, double-blind and controlled trial will rigorously test PUFA effects versus a
placebo in non-demented elders over 3 years. This biomarker based trial will enroll 100
elders. Aim 1 will assess PUFA effects on neuroimaging parameter changes. Aim 2 will assess
PUFA effects on blood-based biomarkers of endothelial health, and Aim 3 will collect
preliminary data on PUFA effects on neuropsychological and functional parameters with special
attention to the executive and speed of processing skills and gait speed.
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