Alzheimer's Disease Clinical Trial
Official title:
Investigation of Biomarkers of Disease State in Alzheimer's Disease and Non-AD Dementias
To establish a cutoff value using a ratio of CSF tau to Aβ42 (tau/Aβ42) for distinguishing patients wth mild to moderate Alzheimer's disease (AD) from health elderly control subjects. The investigators hypothesize that a cutoff can be found that has at least 80% sensitivity and 60% specificity.
This study will enroll 50 AD subjects, 50 normal controls and approximately 20 subjects with
non-AD dementia. There will be 2 visits (up to 30 days apart), and a telephone follow-up
visit.
This protocol does not include treatment of subjects. Lumbar puncture and phlebotomy are
routine clinical tasks and are associated with a low level of risk. All adverse events will
be documented and reviewed by the PI.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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