Alzheimer's Disease Clinical Trial
Amyloid plaques and neurofibrillary tangles are the 2 well-known etiopathological hallmarks
of Alzheimer's disease (AD). Beside these 2 lesions, inflammation response is described in
the brain of patients with AD.
The main objective of our study is to analyse the correlation between the value of plasma
cytokines (interleukin 1, 6, TNFα and chemochine Rantes) and the rapidity of the cognitive
decline in AD over a 2-year follow-up.
Secondary objectives include:
- the predictive value of the cytokines on the cognitive decline after 6 months and one
year of follow-up., of the patients include 150 patients with AD (MMSE: 16-25)
- correlation between plasma cytokines levels and expression of the protein kinase PKR
(involved in death cell) in blood mononuclear cells.
n/a
Intervention Model: Single Group Assignment
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