Hippocampus Study: Comparative Effect of Donepezil 10mg/d and Placebo on Clinical and Radiological Markers

Alzheimer's Disease Clinical Trial

Official title:

Assessment of the Comparative Effect of Donepezil 10mg/d and Placebo on Clinical and Radiological Markers in Patients With Mild Cognitive Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00403520
• Other study ID #: E2020-E033-415
• Status: Completed
• Phase: Phase 4
• First received: November 21, 2006
• Last updated: July 11, 2014
• Start date: November 2006
• Est. completion date: August 2010

Study information

• Verified date: July 2014
• Source: Eisai Inc.
• Contact: n/a
• Is FDA regulated: No
• Health authority: Afsapps: France
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to demonstrate that donepezil slows the progression of Alzheimer's disease (AD) using magnetic resonance imaging (MRI) of the brain to measure the volume of the hippocampus in patients with pre-dementia Alzheimer's disease.

Description:

The development of a new automated method of measurement of the volume of the hippocampus allows confirming these results in patients presenting with pre-dementia Alzheimer's Disease (AD), treated with donepezil in order to verify if this product is capable of stopping the speed of the atrophy of the hippocampus in patients and more specifically in those who will evolve to AD, compared to a placebo. This method is a semi automatic segmentation of the hippocampus from MRI, made by competitive region growing.

It was developed at the cognitive neurosciences and MRI laboratory in Pitié-Salpêtrière hospital. This method was validated on healthy subjects and Alzheimer's disease patients by comparison with manual segmentation.

Neuropsychological tests will be realized in order to supervise the clinical evolution of the patients and to correlate these results to the progression of the atrophy of the hippocampus.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 240
• Est. completion date: August 2010
• Est. primary completion date: March 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 50 Years and older

Eligibility

Inclusion Criteria (Baseline Visit ("V0"):

1.Men or Women 50 years old or more. 2. Patients with mild cognitive impairment (MCI) with progressive hippocampal amnestic syndrome, isolated or associated to other cognitive disorders defined by the Free and cued selective reminding test ( FCSRT ) with Free Recall < or = 17 OR Total Recall < 40 , according to the Grober and Buschke procedure, modified according to the results of PREAL study 3.Clinical Dementia Rating (CDR) = 0.5 4. General cognition and functional performance sufficiently preserved such that a diagnosis of Possible or Probable Alzheimer's Disease based on Diagnostic and Statistical Manual of Mental Disorders DSM-IV criteria) cannot be made by the site physician at the time of the screening visit. This evidence must be fully documented in the subject's study file before the Randomization visit.

5. Outpatient with an informant person: person from his/her close circle having a regular weekly contact with the patient and accepting to answer to assessment questionnaires.

6. Visual, hearing capacities (authorized equipment) and oral or written expression, sufficient for the correct performance of the tests (according to the physician's opinion).

7. Patient and informant person having signed the written informed consent form.

Exclusion Criteria (Baseline Visit ("V0"):

1. Patients with a contraindication to MRI:

• Pacemaker, cardiac defibrillator or neurostimulator wearers

• Wearers of implanted material activated by an electric, magnetic or mechanical system

• Wearers of haemostatic clips of intracerebral aneurysms or carotid arteries

• Wearers of cochlear implants

• Patients with an intraocular metallic foreign body

• Claustrophobic patients

• Any other contra-indication to MRI

2. Patients with an evolutive psychiatric pathology and/or unstable according to DSM-IV, particularly:

• Major depressive episode during the previous 2 years or recurrent depression or bipolar disorders according to the DSM-IV and/or score >= 12 according to the 17-items depressive Hamilton's Scale

• Patients presenting early hallucinations or cognitive fluctuations

3. Patients with neurological disorders:

• Partial complex epilepsy

• Dementia of any origin

• Patients with Parkinson's disease

4. Any patient with a history of an intercurrent lesion found in brain imaging studies.

5. Patient presenting a major repercussion on the autonomy, assessed by Instrumental Activities of Daily Living (IADL) Lawton score higher or equal to 2 in at least 2 items or higher than 2 in at least 1 item, confirmed by an informant person.

6. Patient having less than 14 words at the identification phase of the FCSRT (Free and Cued Selective Reminding Test)

7. Known vitamin B12 or folates deficiency (except if replacement treatment of stable posology since at least 6 months before selection) or known syphilis.

8. Abnormal Thyroid function (T3, T4, ultrasensitive thyroid stimulating hormone (TSH). Euthyroid patients treated with stable doses for at least 3 months could be included.

9. Insulin dependent diabetes or diabetes not controlled by a regimen and/or oral antidiabetics, obstructive pulmonary disease, unstable asthma, recent hematological and/or oncological disorders (2 years).

10. Gastrointestinal, renal, hepatic, endocrine or cardiovascular clinically significant disease. Atrioventricular block of 2nd or 3rd degree on ECG.

11. Patient with bradycardia < or = 50 beats per minute.

12. Patient with unstable hypertension (systolic blood pressure > 160 mmHg and /or diastolic blood pressure > 95 mmHg) assessed by the investigator, the patient being treated or not by antihypertensive drugs.

13. Patient previously treated with central cholinesterase inhibitors or memantine whatever the duration of the treatment and the date of prescription

14. Patient treated by a non-authorized drug during the study

15. Known or suspected history (5 years) of alcoholism, or abusive drug use.

16. Patients with known hypersensitivity to donepezil chlorhydrate, to piperidine derivatives or to one of the excipients of the drug.

17. Patients having participated in a clinical trial during the previous 3 months.

Inclusion criteria (Visit 1):

1. Patients with mild cognitive impairment (MCI) with progressive hippocampal amnestic syndrome, isolated or associated to other cognitive disorders

2. General cognition and functional performance sufficiently preserved such that a diagnosis of Possible or Probable Alzheimer's Disease based on clinical and neuro-imaging findings (NINCDS-ADRDA or DSM-IV criteria) cannot be made by the site physician at the time of the screening visit. This evidence must be fully documented in the subject's study file.

3. Outpatient with an informant person: person from his/her close circle having a regular weekly contact with the patient and accepting to answer to assessment questionnaires

4. Patients having performed an electrocardiogram (ECG) within the previous 6 months

5. Visual, hearing capacities (authorized equipment) and oral or written expression, sufficient for the correct performance of the tests (according to the physician's opinion)

6. Clinical laboratory values must be within normal limits, or if abnormal, judged clinically insignificant by the investigator (not likely to cause cognitive impairment or medical instability)

7. Clinical Dementia Rating (CDR - sum of the boxes) = 0.5

Exclusion criteria (Visit 1):

1. Patients with an evolutive psychiatric pathology and/or unstable according to DSM-IV, particularly:

• Major depressive episode ongoing or recurrent depression or bipolar disorders according to the DSM-IV and/or score >or = 12 according to the 17-items depressive Hamilton's Scale

• Patients presenting early hallucinations or cognitive fluctuations

2. Any patient presenting with an intercurrent lesion in MRI performed at screening must be excluded from the study, apart from minor non-progressive lesions not altering brain morphology

3. Patients with neurological disorders :

• Partial complex epilepsy

• Dementia of any origin

• Patients with Parkinson's disease

4. Patient with One or more MRI Exclusion criteria :

• Stroke sequelae

• More than one ischemic lacuna

• Age related white matter changes on Flair images >Fazekas and Schmidt grade 2

• Active ischemic lesion on Diffusion weighted Images (DWI)

5. Patient presenting a major repercussion on the autonomy, assessed by IADL Lawton score higher or equal to 2 in at least 2 items or higher than 2 in at least 1 item, confirmed by an informant person.

6. Known vitamin B12 or folates deficiency (except if replacement treatment of stable posology since at least 6 months before selection) or known syphilis.

7. Abnormal Thyroid function (T3, T4, free thyroxine index, TSH). Euthyroid patients treated with stable doses for at least 3 months could be included.

8. Insulin dependent diabetes or diabetes not controlled by a regimen and/or oral antidiabetics, obstructive pulmonary disease, unstable asthma, recent hematological and/or oncological disorders (<= 2 years).

9. Gastrointestinal, renal, hepatic, endocrine or cardiovascular clinically significant disease. Atrioventricular block of 2nd or 3rd degree on ECG.

10. Patients with bradycardia <= 50.

11. Patients with unstable hypertension (systolic blood pressure > 160 mmHg and/or diastolic blood pressure > 95mmHg) assessed by the investigator, the patient being treated or not by anti hypertensive drugs.

12. Patient previously treated with central cholinesterase inhibitors or memantine whatever the duration of the treatment and the date of prescription

13. Patient treated by a non-authorized drug during the study

14. Known or suspected history (<= 5 years) of alcoholism, or abusive drug use.

15. Patients with known hypersensitivity to donepezil chlorhydrate, to piperidine derivatives or to one of the excipients of the drug.

16. Patients having participated in a clinical trial during the previous 3 months.

17. Patient treated by a non-authorized drug during the study.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Alzheimer Disease
• Alzheimer's Disease

Intervention

Drug:
• Experimental 1
Drug: Donepezil Hydrochloride 10 mg orally for 12 months
• Placebo Comparator
Drug: Placebo Matching placebo orally for 12 months

Locations

Country	Name	City	State
France	CHU Gui de Chauliac	Montpellier cedex

Sponsors (1)

Lead Sponsor	Collaborator
Eisai Inc.

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evolution of the volume of the Hippocampi, measured by magnetic resonance imaging (MRI), between D0 and final visit (12 months ).		( Day 0 to 12 months or in case of premature withdrawal after 6 months period	No
Secondary	Evolution of the neuropsychological scores between Day 0 and final visit.	Outcome Measure Description: Patients will perform neuropsychological and independence tests including (16 items free recall/cued recall test using the Grober-Buschke method, Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR) sum of the boxes and Instrumental Activities of Daily Living (IADL), and will be evaluated using the Hamilton Scale.	Day 0 to 12 during treatment and at 18 months follow up	No