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Amyloid Plaque and Tangle Imaging in Aging and Dementia

Alzheimer's Disease Clinical Trial

Official title:
Amyloid Plaque and Tangle Imaging in Aging and Dementia

Clinical Trial Summary

Amyloid senile plaques (SPs) and neurofibrillary tangles (NFTs) are neuropathological hallmarks of Alzheimer's disease (AD) that also accumulate in key brain regions in association with normal aging. This project will expand an established program in early detection and prevention of AD designed (1) to identify presymptomatic persons most likely to benefit from early intervention and (2) to provide an objective, noninvasive means to monitor therapeutic trials.

Clinical Trial Description

A total of 165 volunteers will be recruited for this 2-year study. Participants will receive a baseline clinical and imaging evaluation and one follow-up evaluation two years later. These evaluations will include clinical and neuropsychological assessments, structural MRI and/or PET scans. Additional scans and scanning procedures will be performed on a subset of participants and participant visits, including serotonin density levels. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00355498
Study type Observational
Source University of California, Los Angeles
Contact
Status Completed
Phase
Start date September 2005
Completion date May 2010
View Details
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