Computer-Based Training for Mild Alzheimer's Disease

Alzheimer's Disease Clinical Trial

Official title:

Computer-Based Training for Mild Cognitive Impairment and Mild Alzheimer's Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00319891
• Other study ID #: OUT-109-2005
• Status: Completed
• Phase: Phase 1
• First received: April 27, 2006
• Last updated: May 13, 2013
• Start date: September 2004
• Est. completion date: October 2006

Study information

• Verified date: May 2013
• Source: Posit Science Corporation
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The primary objective of this study is to evaluate the effects of computer-based training program ("HiFi-AD") on the memory and cognitive abilities of individuals diagnosed with mild Alzheimer's Disease (AD).

Description:

The purpose of this study is to determine the extent to which computer-based cognitive remediation improves cognitive functions using standardized neuropsychological assessments relevant to AD; 2) the acceptability and feasibility of using computer-based cognitive remediation in an AD population.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 6
• Est. completion date: October 2006
• Est. primary completion date: October 2006
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 60 Years to 90 Years

Eligibility

Inclusion Criteria:

• Fluent in English.

• Mini-Mental Status Examination (MMSE) score of 22 or higher.

• Adequate visual capacity.

• Adequate hearing capacity.

• Has a caregiver with some computer experience.

• Willing and able to commit to the time requirement of the entire study.

Exclusion Criteria:

• Clinically significant cerebrovascular disease.

• Participant is planning to begin acetylcholinesterase inhibitor (AChEI) therapy.

• Participants with severe tremor.

• Axis 1 or 2 psychiatric disorders.

• History of substance abuse.

• History of head trauma.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Alzheimer Disease
• Alzheimer's Disease
• Mild Cognitive Impairment

Intervention

Procedure:
• Computer-based Cognitive Training

Locations

Country	Name	City	State
United States	University of California, San Francisco	San Francisco	California

Sponsors (2)

Lead Sponsor	Collaborator
Posit Science Corporation	University of California, San Francisco

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The primary objective of this trial will be to assess the feasibility of using computer-based
Primary	cognitive training in an a population with early Alzheimer's Disease.
Secondary	A standardized set of neuropsychological assessments will be conducted pre- and post-
Secondary	compuer-based training.