Alzheimer's Disease Clinical Trial
Official title:
Positron Emission Tomography Imaging of Human Brain Phospholipid Metabolism in Relation to Age and Disease
The main source of energy for the brain comes from a combination of oxygen and glucose
(sugar). For brain cells to function normally they must receive a constant supply of these
nutrients. As areas of the brain become more active blood flow into and out of these areas
increase.
In addition to oxygen and glucose, the brain uses chemical compounds known as phospholipids.
These phospholipids make up the covering of nerve cells that assist in the transfer of
information from cell to cell. Without phospholipids brain cell activity may become abnormal
and cause problems in the nervous system.
Certain diseases like Alzheimer's disease and brain tumors can affect blood flow to the
brain and change the way the brain metabolizes phospholipids. In addition to diseases,
changes in the brain occur with normal healthy aging.
This study is designed to use PET scan to measure changes in blood flow and changes in
phospholipid metabolism. Using this technique, researchers can improve their understanding
of how certain diseases change the shape and function of the brain.
Status | Completed |
Enrollment | 123 |
Est. completion date | August 2002 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
NORMAL VOLUNTEERS: Age between 18 and 90 years. No past or current medical condition that would interfere with brain function. No history of alcoholism, psychiatric or neurological illness, head trauma with loss of consciousness, history of exposure to central nervous system toxin; history of central nervous system infection, metabolic, endocrine, connective tissue disease; hypertension or other cardiovascular disorder; abnormal renal, liver or pulmonary function; blood or coagulation disease; malignancy; psychopharmacological treatment; neurodegenerative or neurodevelopmental disorder; stroke; epilepsy; subjects requiring regular medication, and subjects demonstrated by drug screening to have taken a controlled substance. No occupational exposure to metal slivers or shavings. No females who are pregnant or breast feeding. PATIENTS WITH ALZHEIMER DISEASE: Age between 18 and 90 years. Diagnosis of possible or probably Alzheimer Disease according to NINCDS-ADRDA criteria. Aside from Alzheimer Disease, no past or current medical condition that would interfere with brain function. No history of alcoholism, psychiatric or neurological illness, head trauma with loss of consciousness, history of exposure to central nervous system toxin; history of central nervous system infection, metabolic, endocrine, connective tissue diseases; hypertension or other cardiovascular disorder; abnormal renal, liver or pulmonary function; blood or coagulation disease; malignancy; psychopharmacological treatment. No females who are pregnant or breast feeding. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Baudier J, Cole RD. Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids. J Biol Chem. 1987 Dec 25;262(36):17577-83. — View Citation
Belfrage P, Vaughan M. Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res. 1969 May;10(3):341-4. — View Citation
Brooks DJ, Lammertsma AA, Beaney RP, Leenders KL, Buckingham PD, Marshall J, Jones T. Measurement of regional cerebral pH in human subjects using continuous inhalation of 11CO2 and positron emission tomography. J Cereb Blood Flow Metab. 1984 Sep;4(3):458-65. — View Citation
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