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A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK — NIO-SILK  

Alzheimer Disease Clinical Trial

Official title:
A Randomized, Participant & Investigator Blinded, Placebo-Controlled Study to Evaluate the Ability of Intrathecally Administered NIO752 to Lower CSF Total Tau Synthesis in Participants With AD Measured by Stable Isotope Labelling Kinetics

Clinical Trial Summary

This study will assess if drug (NIO752) reduces production of a protein, tau, by the brain. Normally tau maintains the internal skeleton of nerve cells. In Alzheimer's disease (AD) it builds up in the brain, causing damage. Abnormal tau proteins cling to each other forming 'tangles' inside nerve cells, which interfere with how the nerve cells work, and eventually die. This is what causes the symptoms of dementia. It is thought that NIO752 reduces production of tau.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06372821
Study type Interventional
Source University College, London
Contact Ross Paterson
Phone +44(0)2074483875
Email r.paterson@ucl.ac.uk
Status Not yet recruiting
Phase Phase 1
Start date May 2024
Completion date August 2025
View Details
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