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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06148233
Other study ID # KY2023-780
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date September 15, 2023
Est. completion date September 14, 2024

Study information

Verified date November 2023
Source Huashan Hospital
Contact Yihui Guan, MD
Phone 13764308300
Email guanyihui@hotmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To explore the diagnostic value of [18F]CSF-23 brain imaging for CSF1R expression in Alzheimer's disease. PET imaging with this PET tracer was used to assess the role and expression of CSF1R in AD and to evaluate the level and safety of abnormal present imaging.


Recruitment information / eligibility

Status Recruiting
Enrollment 40
Est. completion date September 14, 2024
Est. primary completion date June 16, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 60 Years to 80 Years
Eligibility Inclusion Criteria: - Non-diseased controls: 1. Between 60 and 80 years of age; gender is not limited. 2. Cognitively normal as determined by the investigator through testing, with an MMSE score greater than 25 and no cognitive domain impairment. They had a negative Aß image. 3. No neurological diseases, major chronic diseases, malignant tumors, or acute infectious diseases, as determined by the investigator. 4. Written informed consent must be signed by the subject or his/her legal guardian or caregiver. 5. Blood routine: white blood cell count (WBC) 4~10×109/L; platelet (PLT) 100~300×109/L; hemoglobin (HB) 120~160 g/L; renal function: serum creatinine less than or equal to the upper limit of the normal range; hepatic function: bilirubin, AST (SGOT)/ALT (SGPT) less than or equal to the upper limit of the normal range; Electrocardiogram: no significant abnormalities. 6. No neurological diseases, major chronic diseases, malignant tumors, or acute infectious diseases, as confirmed by the investigator; no family history of neurodegenerative movement disorders, and no family history of neurological disorders related to movement disorders. 7. Willingness and ability to cooperate with all programs of this study. AD patients: 1. Age between 60 and 80 years old; gender is not limited. 2. Patients meet the 2011 NIA-AA diagnostic criteria for red AD patients and have positive Aß images. 3. Brain MRI supported the diagnosis of AD and there was no evidence of other neurological diseases. 4. No neurological diseases, major chronic diseases, malignant tumors or acute infectious diseases, etc., as confirmed by the investigator. 5. Written informed consent must be signed by the subject or his/her legal guardian or caregiver. 6. Blood routine: white blood cell count (WBC) 4~10×109/L; platelet (PLT) 100~300×109/L; hemoglobin (HB) 120~160 g/L; renal function: serum creatinine less than or equal to the upper limit of the normal range; hepatic function: bilirubin, AST (SGOT)/ALT (SGPT) less than or equal to the upper limit of the normal range; ECG: no significant abnormalities. 7. No neurological diseases, major chronic diseases, malignant tumors, or acute infectious diseases, as confirmed by the investigator; no family history of neurodegenerative movement disorders, and no family history of neurological disorders related to movement disorders. 8. Willingness and ability to cooperate with all programs of this study. Exclusion Criteria: - Subjects meeting any of the following criteria will be excluded from the study: 1. Severe hepatic or renal insufficiency; 2. Participation in other research protocols or clinical care within the past year, in addition to the radiation exposure expected from participation in this clinical study, which has resulted in radiation exposure in excess of an effective dose of 50 mSv. 3. Liver function: bilirubin, AST(SGOT)/ALT(SGPT) less than or equal to the upper limit of the normal range. 4. History of serious surgery in the last month. 5. Participation in other clinical trials during the same period.

Study Design


Intervention

Radiation:
[18F]CSF-23
Intravenous injection of 1.8 MBq [0.05MCi]/kg of [18F]CSF-23 in a single dose.

Locations

Country Name City State
China Huashan Hospital Shanghai

Sponsors (1)

Lead Sponsor Collaborator
Huashan Hospital

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Complete PET imaging To assess the diagnostic value of [18F]CSF-23 brain imaging for CSF1R expression in Alzheimer's disease. 90mins from time of injection
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