Autobiographical Specificity

Alzheimer Disease Clinical Trial

— ESAD  

Official title:

Autobiographical Specificity in Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05642351
• Other study ID #: RC22_0626
• Status: Recruiting
• Start date: February 3, 2023
• Est. completion date: February 28, 2025

Study information

• Verified date: February 2023
• Source: Nantes University Hospital
• Contact: Mohamad EL HAJ
• Phone: 02 40 68 66 60
• Email: mohamad.elhaj[@]univ-nantes.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Autobiographical memory is diminished in patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific memories. However, this study proposes a detailed methodology to provide a qualitative analysis of autobiographical specificity.

Description:

Patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia will be invited to retrieve autobiographical memories. Memories will be analyzed and categorized into specific, categoric, extended, or semantic autobiographical retrieval.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 62
• Est. completion date: February 28, 2025
• Est. primary completion date: February 28, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Alzheimer' disease or avioral variant of frontotemporal dementia

• No opposition from the patient to be included in the study

• For Alzheimer's patients: a score of more than 24 out of 30 on the Mini Mental State Examination (McKhann et al., 1984)

Exclusion Criteria:

• Other psychiatric/neurological disorders

• Minor patients

• Adults under guardianship or protection.

Related Conditions & MeSH terms

• Alzheimer Disease
• Aphasia, Primary Progressive
• Dementia
• Frontotemporal Dementia
• Memory
• Pick Disease of the Brain

Intervention

Other:
• Autobiographical reminder
The analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study: 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque") 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962") 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time") 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer") 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque") 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation")

Locations

Country	Name	City	State
France	EL HAJ Mohamad	Nantes

Sponsors (1)

Lead Sponsor	Collaborator
Nantes University Hospital

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Autobiographical specificity	We will apply the method by Raes et al. (2007) to assess whether each retrieved event refers to a: specific event, categorical event, extended event, or semantic event	40 minutes