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NCT05561205 Clinical Trial

rTMS for Apathy Clinical Trial

Alzheimer Disease Clinical Trial

— REACT  

Official title:
Repetitive Transcranial Magnetic Stimulation for Apathy Clinical Trial (REACT)

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05561205
Other study ID # SUN-5342
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date February 9, 2023
Est. completion date December 1, 2024

Study information
Verified date March 2024
Source Sunnybrook Health Sciences Centre
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Apathy is a common, early, and disabling symptom in dementias such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm. Both repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, and methylphenidate, a medication, have been shown to improve apathy. This pilot study will investigate rTMS as a treatment for apathy in AD in individuals receiving methylphenidate and individuals not receiving medication for apathy.

Recruitment information / eligibility
Status Recruiting
Enrollment 8
Est. completion date December 1, 2024
Est. primary completion date December 1, 2024
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Major neurocognitive disorder - Apathy for at least 4 weeks - Stable dose of medication (>4 weeks) that may affect cognition or behaviour - Care partner who spends at least 10 hours a week with the subject Exclusion Criteria: - Current major depressive episode - Agitation, delusions, hallucination - Medical contraindications to rTMS - Currently taking an amphetamine product - Central nervous system abnormalities, Tourette's syndrome, or motor tics - Current participation in another clinical trial

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• rTMS
repetitive transcranial magnetic stimulation
Drug:
• methylphenidate
methylphenidate

Locations
Country Name City State
Canada Sunnybrook Health Sciences Centre Toronto Ontario

Sponsors (1)
Lead Sponsor Collaborator
Sunnybrook Health Sciences Centre

Country where clinical trial is conducted

Canada, 

Outcome
Type Measure Description Time frame Safety issue
Primary Neuropsychiatric Inventory-apathy Measure of apathy on a scale from 0 to 12 with a higher score indicating greater apathy 2 weeks
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