| Eligibility |
Inclusion Criteria:
1. Women of non-childbearing potential and men, aged 50 to 85 years, inclusive, with a
diagnosis of mild to moderate Alzheimer's disease according to the 2018 NIA-AA
criteria and at least a 6-month history of decline in cognitive function documented in
the medical record.
i) Non-childbearing potential for women is defined as postmenopausal (last menses
greater than 24 months) or undergone a documented bilateral tubal ligation or
hysterectomy. If last menses less than 24 months, a serum follicle stimulating hormone
(FSH) value confirming post-menopausal status may be used.
ii) Male participants who are sexually active with a woman of child-bearing potential
must agree to use condoms during the study and for 3 months after last dose. Female
partners should also consider using an acceptable means of birth control, though it is
not mandatory. Acceptable forms of birth control include abstinence, birth control
pills, or any double combination of: intrauterine device (IUD), male or female condom,
diaphragm, sponge, and cervical cap.
2. CSF positive for amyloid beta (as defined in the study manual). Historical CSF results
will be considered provided the results are consistent with the CSF amyloid beta
threshold required for inclusion and following discussion with the medical monitor;
however, an LP is still required as part of screening procedures
3. Neuroimaging (MRI) consistent with the clinical diagnosis of Alzheimer's disease and
without findings of significant exclusionary abnormalities (see Section 9.3 exclusion
criteria no. 4). An historical MRI, up to 1 year prior to screening, may be used as
long as there have been no interval clinical neurologic events that may suggest a
change in the MRI scan.
4. MMSE 18-26 inclusive.
5. Geriatric Depression Scale (GDS) = 6 with no active depression (see Section 9.3
exclusion criteria no. 6).
6. Formal education of 8 or more years.
7. Participants must have a caregiver/study partner who in the opinion of the site's
Principal Investigator, has contact with the study participant for a sufficient number
of hours per week to provide informative responses on the protocol assessments,
oversee the administration of study drug, and is willing and able to participate in
all study site visits and some study assessments. The caregiver/ study partner must
provide written informed consent to participate in the study.
8. Participants living at home or in the community (assisted living acceptable).
9. Participants must have no known history of difficulty swallowing capsules.
10. Stable pharmacological treatment of any other chronic conditions for at least 30 days
prior to screening.
11. Must consent to apolipoprotein E (APOE) genotyping.
12. Participants shall be generally healthy with mobility (ambulatory or ambulatory-aided,
ie, walker or cane), vision and hearing (hearing aid permissible) sufficient for
compliance with testing procedures.
13. Must be able to complete all screening evaluations.
Exclusion Criteria:
1. Hospitalization (except for planned procedures) or change of chronic concomitant
medication within 1 month prior to screening.
2. Participants living in a continuous care nursing facility.
3. Contraindications to the MRI examination for any reason.
4. Screening MRI (or historical MRI, if applicable) of the brain indicative of
significant abnormality, including, but not limited to, prior hemorrhage or infarct >
1 cm3, > 3 lacunar infarcts, cerebral contusion, encephalomalacia, aneurysm, vascular
malformation, subdural hematoma, hydrocephalus, space-occupying lesion (eg, abscess or
brain tumor such as meningioma).
5. Clinical or laboratory findings consistent with:
1. Other primary degenerative dementia, (dementia with Lewy bodies, fronto-temporal
dementia, Huntington's disease, Creutzfeldt-Jakob Disease, Down syndrome, etc).
2. Other neurodegenerative condition (Parkinson's disease, amyotrophic lateral
sclerosis, etc).
3. Seizure disorder.
4. Other infectious, metabolic or systemic diseases affecting the central nervous
system (syphilis, present hypothyroidism, present vitamin B12 or folate
deficiency, other laboratory values etc).
6. A current DSM-V diagnosis of active major depression, schizophrenia or bipolar
disorder. Participants with depressive symptoms successfully managed by a stable dose
of an antidepressant are allowed entry.
7. Clinically significant, advanced or unstable disease that may interfere with outcome
evaluations, such as:
1. Chronic liver disease, liver function test abnormalities or other signs of
hepatic insufficiency (ALT, AST, alkaline phosphatase > 1.5 ULN, lactate
dehydrogenase (LDH) > 1.5 x ULN).
2. Respiratory insufficiency.
3. Renal insufficiency eGFR < 50 mL/min based on the CKD-EPI formula,
4. Heart disease (myocardial infarction, unstable angina, heart failure,
cardiomyopathy within 6 months before screening).
5. Bradycardia (< 50/min.) or tachycardia (> 100/min.).
6. Poorly managed hypertension (systolic > 160 mm Hg and/or diastolic > 95 mm Hg) or
hypotension (systolic < 90 mm Hg and/or diastolic < 60 mm Hg).
7. Uncontrolled diabetes in known diabetics, as defined by hemoglobin A1c (HbA1c) >
7.5.
8. History of cancer within 3 years of screening with the exception of fully excised
non-melanoma skin cancers or non-metastatic prostate cancer that has been stable for
at least 6 months.
9. Seropositive for human immunodeficiency virus (HIV).
10. History of acute/chronic hepatitis B or C and/or carriers of hepatitis B (seropositive
for hepatitis B surface antigen [HbsAg] or anti-hepatitis C [HCV] antibody).
11. Clinically significant abnormalities in screening laboratory tests, including:
a) Hematocrit less than 35% for males and less than 32% for females, absolute
neutrophil cell count of <1500/uL (with the exception of a documented history of a
chronic benign neutropenia), or platelet cell count of < 120,000/uL; international
normalized ratio (INR) > 1.4 or other coagulopathy, confirmed by repeat assessment.
12. Disability that may prevent the participant from completing all study requirements
(e.g., blindness, deafness, severe language difficulty, etc).
13. Within 4 weeks of screening visit or during the study, concurrent treatment with
antipsychotic agents, antiepileptics, centrally active anti-hypertensive drugs (e.g.,
clonidine, l-methyl dopa, guanidine, guanfacine, etc), sedatives, opioids, mood
stabilizers (e.g., valproate, lithium); or benzodiazepines, with the following
exception:
a) Low dose lorazepam may be used for sedation prior to MRI scan for those
participants requiring sedation. At the discretion of the Investigator, 0.5 to 1 mg
may be given orally prior to scan with a single repeat dose given if the first dose is
ineffective. No more than a total of 2 mg lorazepam may be used for the MRI scan.
14. Any disorder that could interfere with the absorption, distribution, metabolism or
excretion of drugs (eg, small bowel disease, Crohn's disease, celiac disease, or liver
disease).
15. Nootropic drugs except stable AD meds (acetylcholinesterase inhibitors and memantine).
16. Suspected or known drug or alcohol abuse, ie, more than approximately 60 g alcohol
(approximately 1 liter of beer or 0.5 liter of wine) per day.
17. Suspected or known allergy to any components of the study treatments.
18. Enrollment in another investigational study or intake of investigational drug within
the previous 30 days or 5 half-lives of the investigational drug, whichever is longer.
19. Intake of drugs or substances potentially involved in clinically significant induction
or inhibition of CYP3A4 or P-gp mediated drug interactions with CT1812, within 4 weeks
or 5 half-lives of the interacting drug prior to administration of CT1812 and
throughout the study. Grapefruit juice should be avoided in the 2 weeks prior to
dosing and throughout the study. See Appendix A for a complete list of prohibited
substances.
20. Exposure to immunomodulators, anti Aß vaccines, passive immunotherapies for AD (e.g.,
monoclonal antibodies) within the past 180 days and/or exposure to BACE inhibitors
within the past 30 days
21. Anticipated use of nonsteroidal anti-inflammatory drugs (NSAIDs) on more than 14 days
from Baseline/Day 1 to Day 182. Contraindication to undergoing an LP including, but
not limited to: inability to tolerate an appropriately flexed position for the time
necessary to perform an LP; international normalized ratio (INR) > 1.4 or other
coagulopathy; platelet count of < 120,000/µL; infection at the desired LP site; taking
anti-coagulant medication within 90 days of screening (low-dose aspirin is permitted);
degenerative arthritis of the lumbar spine; suspected non-communicating hydrocephalus
or intracranial mass; prior history of spinal mass or trauma.
22. Any condition, which in the opinion of the Investigator or the Sponsor, makes the
participant unsuitable for inclusion.
|
