Alzheimer Disease Clinical Trial
Official title:
Single-center, Open, Prospective, Single-arm, Feasibility, Investigator-initiated Trail for Assessment of Initial Efficacy and Safety of High Intensity Focused Ultrasound 'ExAblate 4000 Type 2' for Blood Brain Barrier Disruption in Patients With Alzheimer's Disease
The proposed study is to evaluate initial efficacy and safety of the BBB disruption with
transcranial MRI-guided focused ultrasound (ExAblate 4000 type 2.0) in patients with
Alzheimer's disease.
This study iw designed as a prospective, single-site, single-aarm, nonrandomized study.
Assessments will be made before and three months after 2 sessions of BBB disruption with
radiologic, nuclear medicine imaging and neurophysiological examinations. Relative safety
will be evaluated using a common description of Significant Clinical Complications for
patients treated in this study.
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