Alzheimer Disease Clinical Trial
Official title:
Multimodal Imaging Study on Physical Activity in Patients With Alzheimer`s Disease
This study aims to gain a better understanding of metabolic early changes in
neurodegenerative diseases, in order to enable new diagnostic and therapeutic approaches in
the future. Further, it aims to identify specific movement-induced changes at the cerebral
level, on cognition, on quality of life and physical fitness, and on serology parameters in
neurodegenerative diseases.
In general, valid biomarkers are needed for early diagnosis and prediction of disease
progression. It has been hypothesized that metabolic changes may precede structural changes
and may be examined by intervention with exercise therapy. The non-invasive, in vivo
characterization and diagnosis of such metabolic changes is therefore of paramount
importance. In this line, this research project is focused on applying magnetic resonance
imaging (MRI) based metabolic imaging techniques such as sodium MRI and phosphorus magnetic
resonance spectroscopy (MRS) with standard structural and functional MRI methods, combined
with exercise training, in order to detect biomarkers early in different stages of
neurodegenerative diseases. Moreover, this project aims to examine the sensitivity of
metabolic imaging with sodium and phosphorus sequences over classical MRI imaging with whole
body fat sequences, in order to detect cerebral alterations.
At the end, the medical benefit of the planned project lies in the fact that the expected
findings are groundbreaking for the understanding of the phenomenology and pathobiology of
neurodegenerative diseases. This is the basis for the development of new methods for early
diagnosis and individualized medicine with the optimization of future treatment options.
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