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Imaging of Brain Structural/Functional Connectivity and Amyloid and Tau Lesions in APOE4 Carriers. — Protocol_Z  

Alzheimer Disease Clinical Trial

Official title:
Imaging of Brain Structural/Functional Connectivity and Amyloid and Tau Lesions in APOE4 Carriers. (IND 123119, Protocol Z)

Clinical Trial Summary

To advance current knowledge on the vascular contributions to dementia

Clinical Trial Description

This is a multi-center study at Washington University (WASH U), University of Southern California (USC), and Huntington Medical Research Institute (HMRI).The overall goal of both the AA program and the PPG program is to advance current knowledge on the vascular contributions to dementia particularly in individuals with the major genetic risk factor for late-onset AD, i.e., apolipoprotein E-ε4 (APOE4) gene that develop early vascular dysfunction and significant cerebrovascular pathology compared to non-carriers, and establish whether the neurovasculature plays a key role in cognitive decline, and therefore is a key new therapeutic target to treat dementia in APOE4 carriers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03816228
Study type Observational
Source Washington University School of Medicine
Contact
Status Withdrawn
Phase
Start date January 2022
Completion date October 11, 2022
View Details
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