Alzheimer Prevention Trials (APT) Webstudy

Alzheimer Disease Clinical Trial

Official title:

Alzheimer Prevention Trials (APT) Webstudy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03638583
• Other study ID #: HS-17-00746
• Secondary ID: R01AG053798
• Status: Recruiting
• Start date: December 20, 2017
• Est. completion date: April 30, 2026

Study information

• Verified date: August 2023
• Source: University of Southern California
• Contact: APT Webstudy Team
• Phone: 858-877-3135
• Email: info[@]aptwebstudy.org
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The goal of the Alzheimer Prevention Trials (APT) Webstudy is to accelerate enrollment for Alzheimer's disease (AD) clinical trials by identifying and tracking individuals who may be at higher risk for developing AD dementia.

Description:

The APT Webstudy will use web-based cognitive testing and questionnaires to generate a risk score which will be used to identify individuals who may be at an increased risk for developing AD dementia. Individuals who join the APT Webstudy will register at https://www.aptwebstudy.org/, sign an electronic informed consent form (ICF), provide basic demographic information and participate in web-based cognitive testing. Participants will return the APT Webstudy quarterly (every 3 months) to complete the cognitive testing again. Based on the risk score and changes identified in the cognitive testing results, participants will be invited to visit a partnering clinical trial site for an in-person visit with biomarker testing and clinical assessment. The combined results of the web-based assessments, with the biomarker and clinical assessments, will allow an adaptive statistical algorithm to improve the selection of those at highest risk for developing AD. To Join the APT Webstudy, please visit https://www.aptwebstudy.org/.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200000
• Est. completion date: April 30, 2026
• Est. primary completion date: April 30, 2026
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 85 Years

Eligibility

Inclusion Criteria:

• male or female at least 50 years of age
• no evidence of dementia
• willing to participate in remote longitudinal cognitive testing and possible referral for biomarker assessment based on risk

Exclusion Criteria:

• N/A. Anyone can register for the APT Webstudy, however, only individuals identified using the risk algorithm will be referred for in-person biomarker assessments.

Related Conditions & MeSH terms

• Alzheimer Disease
• Dementia

Locations

Country	Name	City	State
United States	Https://Www.Aptwebstudy.Org	San Diego	California

Sponsors (4)

Lead Sponsor	Collaborator
University of Southern California	Brigham and Women's Hospital, National Institute on Aging (NIA), The Cleveland Clinic

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Enrollment into Alzheimer's prevention research studies		5 years
Secondary	Referral into prevention research studies		5 years
Secondary	Number of individuals enrolled into Alzheimer's prevention studies		5 years