Alzheimer Disease Clinical Trial
Official title:
Enteric Nervous System in Alzheimer Disease
The close homology between the central and enteric nervous systems suggests that a disease
process affecting the central nervous system could also involve its enteric counterpart. The
investigators have recently shown in that the enteric neurons can be readily analyzed using
routine colonic biopsies. This led us to propose that the enteric nervous system could
represent a unique window to assess the neuropathology in living patients with a
neurodegenerative disorder. The investigators have already used this approach to show that
Parkinson's disease pathology was recapitulated in a single colonic biopsy. By contrast to
Parkinson's disease, the detection of Alzheimer's disease (AD) pathology in the enteric
neurons has so far failed. This may be due to the low number of human tissue samples in
addition to the low sensitivity of the immunohistochemical methods that were used. The aim
of the current research project will be therefore to reevaluate AD pathology in a large
number of human colonic samples using both a morphological and biochemical approach .
The enteric nervous system could represent a unique window to assess the neuropathology in
living patients with AD. This might open the way to the development of novel AD biomarkers
that will directly assess the neuropathological process.
Main Aim : To Analyze the presence of beta-amyloid pathology in the enteric nervous system
(ENS) in AD patients
Secondary Aim(s):
1. To analyze and describe the presence of tau in the enteric nervous system (ENS) in AD
patients
2. To assess neuronal loss in submucosal tissue in AD patients.
3. To examine Glia cells in the enteric nervous system in AD patients..
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label
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