Alzheimer Disease Clinical Trial
— TAMAOfficial title:
Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease
In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.
Status | Recruiting |
Enrollment | 155 |
Est. completion date | December 2023 |
Est. primary completion date | December 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 85 Years |
Eligibility | Inclusion Criteria: - Patients - Age between 40 and 85 - French mother tongue - Consulting at the Amiens Memory Resource and Research Centre (CMRR) for: - MCI, according to Albert et al.'s criteria (Albert et al., 2011) - Mild dementia (MMSE>20) due to AD, according to McKhann's criteria (McKhann et al., 2011). - Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005). - Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011). - Social security coverage - Healthy controls - Healthy age and gender matched volunteers will be recruited into the study from the general population. Exclusion Criteria: - Reading or writing difficulties related to a learning disorder or illiteracy. - A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure): - NYHA stage IV dyspnoea. - respiratory impairment requiring oxygen therapy. - liver impairment. - kidney failure, progressing neoplastic disease, or past or present alcohol abuse. - Past or present neurological disorders other than those having prompted consultation in the Memory Clinic: - stroke. - meningitis or encephalitis. - severe head injury. - sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments). - epilepsy (requiring ongoing treatment), - psychiatric disorders (other than treated depression). - treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state. - Impossibility to perform a neuropsychological evaluation or brain MRI. - Withdrawal from the study at any time, if desired. - Pregnancy - Contra-indication to MRI: - nerve stimulators - cochlear implants - ferromagnetic foreign bodies close to nervous structures in the eye or brain - cerebral shunts - dental appliances - Legal guardianship or incarceration. |
Country | Name | City | State |
---|---|---|---|
France | CHU Amiens | Amiens |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire, Amiens |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | median SRT (simple reaction time) to a stimulus (in milliseconds) | Day 0 |
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