Self-consciousness in Dementia

Alzheimer Disease Clinical Trial

Official title:

Self-consciousness in Dementia

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01782248
• Other study ID #: 5289
• Secondary ID: 5289
• Status: Recruiting
• Phase: N/A
• Start date: March 13, 2013
• Est. completion date: March 12, 2022

Study information

• Verified date: September 2020
• Source: University Hospital, Strasbourg, France
• Contact: Nathalie PHILIPPI, MD
• Phone: 3 88 12 86 33
• Email: nathalie.philippi[@]chru-strasbourg.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to characterize the deficit in critical components of personal identity (self-consciousness and social cognition) in patients with Alzheimer's disease (AD) and fronto-temporal lobar dementia (FTLD), compared to healthy elderly, combining a neuropsychology and multi-podal neuroimaging study.

We posit that the alteration of some aspects of self-consciousness (autobiographical memory, nosognosia, metacognition) and social cognition (theory of mind and facial) results in personality changes in the patients, primarily due to the alteration of self-consciousness in AD and to social cognition in FTLD.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 65
• Est. completion date: March 12, 2022
• Est. primary completion date: March 12, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 45 Years to 85 Years

Eligibility

Inclusion Criteria:

• AD (McKhann et al, 1984 and Dubois et al, 2007) or FTLD (Neary et al, 1998 or Rascovsky et al, 2011)

• MMSE > or = 18

• Relative avaible

Exclusion Criteria:

• Contraindication to MRI

• Major depression

• Other central neurological condition

Related Conditions & MeSH terms

• Alzheimer Disease
• Dementia
• Fronto-temporal Lobar Dementia

Intervention

Other:
• Questionnary and IRM

Locations

Country	Name	City	State
France	Hôpitaux Universitaires de Strasbourg	Strasbourg

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Strasbourg, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Characterize the deficit in critical components of personal identity in patients with Alzheimer's disease (AD) and fronto-temporal lobar dementia (FTLD), compared to healthy elderly, combining a neuropsychology and multi-podal neuroimaging study.		each month for 3 month