Alzheimer Disease Clinical Trial
Official title:
Effects of a Combined TMS Stimulation and Cognitive Training in Alzheimer Patients: a Single-center, Randomized, Double-blind, Placebo-controlled Study
The aim of this study is to examine if combined treatment with TMS and cognitive training (CoTra) for several weeks can produce a sustained improvement in cognitive and behavioral symptomatology of mild to moderate Alzheimer's disease (AD) patients.
The current available pharmaceutical treatment for Alzheimer Disease (AD) is only partially
and temporary effective. Therefore, new approaches are needed. rTMS is a non-invasive
technique which generates a small electric current that induces a modulation in cortical
excitability. In addition, cognitive training was suggested to improve cognitive functions
in Alzheimer patients.
In this study we intend to treat mild to moderate AD patients with rTMS interlaced with
cognitive training (rTMS- COG).
Patients with probable AD will be treated with rTMS-COG daily for 6 weeks followed by
maintenance sessions for additional 3 months.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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