Alzheimer Disease Clinical Trial
Official title:
Anti-Inflammation in AD: PET Imaging Supplement
The purpose of this study is to determine whether the anti-inflammatory drug celecoxib can delay the onset of Alzheimer Disease (AD) in people with Age Associated Memory Impairment (AAMI). This study will also evaluate genetic risk and brain structure as potential predictors of mental decline.
AD is one of the most common mental disorders of late life. Preliminary studies indicate that
anti-inflammatory drugs may attenuate or prevent AD symptoms, but efficacy trials are needed.
Participants in this study will be randomly assigned to receive either celecoxib or placebo
for 18 months. Participants will undergo positron emission tomography (PET) and magnetic
resonance imaging (MRI) scans of the brain. Routine laboratory blood tests, cognitive tests,
and an electrocardiogram (ECG) will be performed. Participants will also be screened for
Parkinson disease. Follow-up testing will be conducted at specific intervals following the
study.
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