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Alzheimer Disease clinical trials

View clinical trials related to Alzheimer Disease.

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NCT ID: NCT05421728 Enrolling by invitation - Primary Health Care Clinical Trials

Effectiveness of Engaging in Advance Care Planning Talks (ENACT) Group Visits in Primary Care for Older Adults With and Without Alzheimer's Disease

ENACT
Start date: July 26, 2022
Phase: N/A
Study type: Interventional

The main goal of the ENACT (ENgaging in Advance Care planning Talks) Group Visit intervention is to integrate a patient-centered advance care planning process into primary care, ultimately helping patients to receive medical care that is aligned with their values. The ENACT Group Visit intervention involves two group discussions about advance care planning with 8-10 patients who meet for 2-hour sessions, one month apart, facilitated by a geriatrician and a social worker. This study will compare the ENACT Group Visit intervention to mailed advance care planning materials.

NCT ID: NCT05216315 Enrolling by invitation - Alzheimer Disease Clinical Trials

tDCS and Cognitive Efficiency

FRtDCS
Start date: July 30, 2020
Phase: N/A
Study type: Interventional

Normal aging is associated with a progressive decline in cognitive functions, especially memory. This decline in cognitive function can negatively impact the quality of life of older adults. Although there are currently few possibilities to prevent and/or slow the signs of cognitive decline, both those associated with age and neurodegenerative pathologies, one of the non-invasive brain stimulation techniques that has gained attention in recent years is Transcranial Direct Current Stimulation (tDCS). tDCS is a technique based on the application of a low-intensity (< 2 mA) direct electrical current between two large-area electrodes placed on various surface areas of the head. Moreover, according to safety-related meta-analyses it is a very safe technique, without any major side effects, provided that internationally established safety protocols are taken into account in its application. This technique has recently been investigated as a potential treatment for both healthy elderly people and people with mild cognitive impairment and Alzheimer's disease in several cognitive variables, having shown encouraging results in working memory learning curves, modulation of plasticity and recognition tasks. This project aims to implement an intervention using transcranial direct current stimulation in healthy older adults, MCI and AD. The main objective is to test if there is an improvement in cognitive efficiency and if the changes are maintained over time (1 month). For this purpose, the effect of the technique will be studied on participants assigned to treatment and control groups, analyzing the possible modifications in the following cognitive variables: cognitive plasticity and learning potential, recognition and familiarity and false alarms.

NCT ID: NCT05076331 Enrolling by invitation - Alzheimer Disease Clinical Trials

Health and Aging Brain Study: Health Disparities Tau Positron Emission Tomography (PET) Scan Study

Start date: April 20, 2021
Phase:
Study type: Observational

The purpose of this project is to study the aging brain among participants enrolled in the Health and Aging Brain Study: Health Disparities project . There are a number of things that can influence how people think as they age, including diabetes, depression, as well as our biology. In this study, the investigators seek to study the aging brain by using brain PET scans that create detailed pictures of the brain.

NCT ID: NCT04954183 Enrolling by invitation - Alzheimer Disease Clinical Trials

Development of an EEG Diagnostic for Alzheimer's Disease

Start date: October 1, 2021
Phase:
Study type: Observational

The purpose of this research is to collect and compare electroencephalogram data from all stages of Alzheimer's disease from preclinical through severe dementia.

NCT ID: NCT04949529 Enrolling by invitation - Alzheimer Disease Clinical Trials

Falls: A Marker of Preclinical AD

Start date: March 7, 2019
Phase:
Study type: Observational

This longitudinal cohort study investigates cognitively normal participants with and without preclinical Alzheimer disease (AD) in order to examine: (1) the relationship between falls and functional mobility in preclinical stages of AD; and (2) a hypothesized model of central and peripheral mechanism(s) underlying falls and functional mobility in preclinical stages of AD.

NCT ID: NCT04948866 Enrolling by invitation - Alzheimer Disease Clinical Trials

Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers

ADRD-PC
Start date: July 26, 2021
Phase: N/A
Study type: Interventional

Millions of Americans have late-stage Alzheimer's and related dementias (ADRD), causing suffering due to loss of awareness of self and family, progressive dependency, physical and neuropsychiatric symptoms, and physical, emotional and financial strain for caregivers. Investigators now propose a multi-site randomized clinical trial of the ADRD Palliative Care (ADRD-PC) program for persons with late-stage ADRD and their family caregivers, triggered during hospitalization. Investigators aim to learn if this program of dementia-specific palliative care, standardized caregiver education, and transitional care is effective to reduce burdensome hospital transfers, improve symptom treatment and control, augment supportive services, and reduce nursing home transitions for patients, and to improve caregiver outcomes of communication, shared decision-making and distress.

NCT ID: NCT04947553 Enrolling by invitation - Alzheimer Disease Clinical Trials

A Study to Assess the Long-term Safety and Efficacy of AXS-05 in Subjects With Alzheimer's Disease Agitation

Start date: June 17, 2021
Phase: Phase 3
Study type: Interventional

This study will evaluate the long-term safety and efficacy of AXS-05 in subjects with Alzheimer's disease (AD) agitation.

NCT ID: NCT04932473 Enrolling by invitation - Clinical trials for Cognitively Unimpaied

ALFAsleep: Exploring Cognitive and Biological Correlates of Sleep Quality and Their Potential Links With Alzheimer's Disease

Start date: January 26, 2021
Phase:
Study type: Observational

The main goal of this study is to perform a multimodal characterization of brain structural and functional changes, as well as changes in Alzheimer's disease (AD) biomarkers, as a function of sleep quality measures. Cross-sectional data will enable us to confirm and expand previous knowledge in a large and well-phenotyped population, while longitudinal data will allow us to test the hypothesis of the existence of a bidirectional relationship between sleep quality and AD.

NCT ID: NCT04905238 Enrolling by invitation - Clinical trials for Sleep Apnea, Obstructive

Obstructive Sleep Apnea Snd Biomarkers of Alzheimer's Disease

Start date: July 31, 2020
Phase: N/A
Study type: Interventional

Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To compare biomarkers of Alzheimer's disease in plasma samples from patients with Obstructive sleep apnea (OSA) and without OSA. 2) To determine if CPAP reduces biomarkers of Alzheimer's disease in plasma samples.

NCT ID: NCT04886063 Enrolling by invitation - Alzheimer Disease Clinical Trials

Open Label Study of ATH-1017 for Treatment of Mild to Moderate Alzheimer's Disease

Start date: June 30, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

The objective of this study is to determine the safety and tolerability of fosgonimeton (ATH-1017) in subjects with mild to moderate Alzheimer's disease who completed the 26-week randomized treatment in Study ATH-1017-AD-0201 or Study ATH-1017-AD-0202.