Bone Healing in Immediate Dental Implants

Alveolar Bone Loss Clinical Trial

Official title:

Effect of PRP on Bone Healing in Immediate Implants Analyzed by CBCT

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04650763
• Other study ID #: Case # 466/ERC/CMH/LMC
• Status: Completed
• Phase: N/A
• Start date: October 2, 2017
• Est. completion date: March 30, 2018

Study information

• Verified date: November 2020
• Source: CMH Lahore Medical And Dental College
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To study the effect of platelet-rich plasma concentrate on marginal bone loss and bone mineral density in immediate implant placement through CBCT.

Description:

12 subjects were equally categorized into two groups. Group, I was the control group; whereas, the subjects in Group II received Platelet Rich Plasma (PRP) therapy. All subjects were given a standard treatment with single implant system. Inserted implants were analyzed through Cone Beam Computerized Tomography (CBCT). Records were registered at the baseline, at 12th week before functional loading and 26th week after functional loading.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: March 30, 2018
• Est. primary completion date: March 30, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 50 Years

Eligibility

Inclusion Criteria:

• patients maintaining good oral hygiene, having adequate bone quantity at the implant site, uneventful extraction

Exclusion Criteria:

• Active infection around implant site, immunocompromised state, with current major systemic disease (uncontrolled diabetes, rheumatoid arthritis, etc.) or oral pathologies, history of bleeding disorders or on anticoagulant therapy, or patients on bisphosphonates were excluded from the study

Related Conditions & MeSH terms

• Alveolar Bone Loss
• Platelet Rich Plasma

Intervention

Biological:
• PRP injection
PRP was prepared using patient's blood and mixed with saline or mixture of calcium chloride and thrombin to form a liquid solution; in order to inject at the surgical site after placement of implant.

Device:
• Automated blood cell separator to extract PRP
Blood was withdrawn from antecubital vein and mixed with anticoagulant. Blood sample was then centrifuged to obtain platelet rich plasma which was injected at surgical site after implant placement.

Locations

Country	Name	City	State
Pakistan	Institute of Dentistry; CMH Lahore Medical College	Lahore	Punjab

Sponsors (1)

Lead Sponsor	Collaborator
CMH Lahore Medical And Dental College

Country where clinical trial is conducted

Pakistan, 

References & Publications (1)

Boora P, Rathee M, Bhoria M. Effect of Platelet Rich Fibrin (PRF) on Peri-implant Soft Tissue and Crestal Bone in One-Stage Implant Placement: A Randomized Controlled Trial. J Clin Diagn Res. 2015 Apr;9(4):ZC18-21. doi: 10.7860/JCDR/2015/12636.5788. Epub — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Bone Mineral Density	Measurement in Hounsfield number	Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT
Primary	Measurement of bone loss at baseline (12 weeks) and later at 26weeks	Measurement at mesial in mm	Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT
Secondary	Measurement of bone loss at baseline (12 weeks) and later at 26weeks	Measurement at distal in mm	Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT