Alveolar Bone Loss Clinical Trial
Official title:
The Influence of Cortical Bone Perforation on Guided Bone Regeneration in Humans: A Randomized Clinical Trial
The purpose of this randomized clinical trial was to evaluate the effect of cortical bone decortication on the angiogenesis and osteogenesis of augmented ridge by GBR.
Background: The purpose of the current study was to evaluate the effect of cortical bone
perforation on angiogenesis and osteogenesis of augmented ridge by guided bone regeneration.
Methods: Fourteen patients (mean age: 52) who were in need of dental implants at areas with
osseous defects in the mandible were selected. In the test group (n=7), alveolar cortical
bone at the area of regeneration was perforated using a #2 high speed round bur. No
decortication of cortical bone was performed in the control group (n=7). Subsequently,
defects were augmented by guided bone regeneration using resorbable membrane and bovine
bone. After a healing period of 7 months, implant sites were created and trephine cores
harvested for histological and histomorphometric analysis of the grafted areas.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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