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Clinical Trial Summary

A randomized controlled clinical multi center trial to assess the efficacy of a combination of autologous mesenchymal stem cells and biomaterial in jaw bone regeneration prior to dental implant placement in comparison to standard autologous bone block grafting.


Clinical Trial Description

A phase III multi center clinical trial, randomized and controlled.The study subject is lacking one or more sheet behind the canine in the upper or lower jaw, and the alveolar ridge is too narrow to place a dental implant. The test objects will have augmentation using autologous mesenchymal stromal cells and a biomaterial, biphasic Calcium Phosphate. The control is the traditional bone block from the ramus. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04297813
Study type Interventional
Source University of Bergen
Contact Kamal Mustafa, Professor
Phone +47 98497607
Email kamal.mustafa@uib.no
Status Recruiting
Phase Phase 3
Start date March 2020
Completion date September 2024

See also
  Status Clinical Trial Phase
Enrolling by invitation NCT02209311 - Effectiveness and Safety of Method of Maxilla Alveolar Process Reconstruction Using Synthetic Tricalcium Phosphate and Autologous MMSCs Phase 1/Phase 2
Enrolling by invitation NCT02293031 - Gene-activated Matrix for Bone Tissue Repair in Maxillofacial Surgery N/A
Completed NCT03357068 - Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans N/A
Completed NCT01268982 - Effect of Socket Preservation Procedure on Dimensional Changes of the Ridge, and Its Efficacy. Phase 2
Completed NCT00868777 - The Influence of Dimensional Anatomic Variables on the Outcomes of Maxillary Sinus Grafting Procedures Phase 4
Completed NCT04506827 - RCT With 3 Different Biomaterials for Maxillary Sinus Lift Phase 4
Not yet recruiting NCT04998058 - Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting Phase 1/Phase 2