Genetics of Alpha Thalassemia in Israeli Ethnic Groups

Alpha Thalassemia Clinical Trial

Official title:

Haplotype Analysis of Alpha Globin Genes in Israeli Ethnic Groups

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00159029
• Other study ID #: 152910-HMO-CTIL
• Status: Completed
• Phase: N/A
• First received: September 9, 2005
• Last updated: August 9, 2017
• Start date: April 1, 2004
• Est. completion date: July 1, 2017

Study information

• Verified date: August 2017
• Source: Hadassah Medical Organization
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.

Description:

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: July 1, 2017
• Est. primary completion date: July 1, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• diagnosis of deletional alpha thalassemia

Exclusion Criteria:

• under age 18

Related Conditions & MeSH terms

• Alpha Thalassemia
• alpha-Thalassemia
• Thalassemia

Locations

Country	Name	City	State
Israel	Hadassah Medical Organization	Jerusalem

Sponsors (1)

Lead Sponsor	Collaborator
Deborah Rund

Country where clinical trial is conducted

Israel, 

References & Publications (1)

Rund D, Filon D, Jackson N, Asher N, Oron-Karni V, Sacha T, Czekalska S, Oppenheim A. An unexpectedly high frequency of heterozygosity for alpha-thalassemia in Ashkenazi Jews. Blood Cells Mol Dis. 2004 Jul-Aug;33(1):1-3. — View Citation