Alopecia, Androgenetic Clinical Trial
Official title:
Comparing Platelet-Rich Plasma (PRP) Centrifugation Methods on Thrombocyte Concentration and Clinical Improvement of Androgenetic Alopecia: A Preliminary, Randomized, Double-Blind Clinical Trial
Verified date | January 2023 |
Source | Indonesia University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This research is a preliminary, randomized, double blind clinical trial, which will examine the differences in PRP preparation methods, a single-spin centrifugation of 3000 rpm in 15 minutes compared to a double-spin centrifugation of 1500 rpm in 6 minutes followed by 2500 rpm in 15 minutes, on the results of Thrombocyte Concentration and Clinical Improvement of Androgenetic Alopecia.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | February 2023 |
Est. primary completion date | February 2023 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 25 Years to 59 Years |
Eligibility | Inclusion Criteria: - Met the criteria of androgenic alopecia (Hamilton Norwood grade III-IV) - Men between ages 25-59 years old - Have stopped taking topical anti-androgen or minoxidil for at least one month, or oral anti-androgen or minoxidil for at least three months Exclusion Criteria: - alopecia of any other type - subject with a history of keloid or blood coagulation disorders underwent anticoagulant therapy - subjects on Non-Steroidal Anti-Inflammatory Drugs (NSAID) medications in seven days prior to the study - subjects who had hair treatment using growth factors, including PRP and microneedling within at least six months prior to the study. |
Country | Name | City | State |
---|---|---|---|
Indonesia | Cipto Mangunkusumo General Hospital | Jakarta Pusat | DKI Jakarta |
Indonesia | Universitas Indonesia | Jakarta Pusat | Jakarta |
Lead Sponsor | Collaborator |
---|---|
Indonesia University |
Indonesia,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Thrombocyte Count in PRP and Whole Blood | We assessed the increase in PRP platelet levels by assessing baseline platelets (using whole blood) and assessing platelet levels in PRP preparations and then calculating multiples. platelet valuie units to be used is (/µL) | 6 weeks | |
Primary | Clinical Improvement of Androgenetic Alopecia | We assessed the assessment of clinical improvement in androgenetic alopecia using trichoscopy and trichoscan examination on week 0, 2, 4, and 6. On trichoscopic examination we assessed hair color, hair diameter diversity, vellus hair, and dots. Whereas on trichoscan examination we assessed hair count, hair diameter (mm), hair density (/cm2), hair rate (%) in vellus hair, terminal, anagen and telogen phases and assessed hair mean thickness (mm/cm2) and mean length (mm) and average hair per unit. | 6 weeks |
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