Allergy Clinical Trial
Official title:
A Randomized, Double-blinded, Controlled Trial of Adding a Short Burst of Corticosteroid to the Conventional Treatment of H1 Antihistamines
Verified date | January 2020 |
Source | Chulalongkorn University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
A randomized, double-blinded, controlled trial of adding a short burst of corticosteroid to the conventional treatment of H1 antihistamines
Status | Completed |
Enrollment | 75 |
Est. completion date | October 31, 2019 |
Est. primary completion date | October 31, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Patients visit emergency room at King chulalongkorn memorial hospital (KCMH) age between 18-50 years who meet the following criteria of acute urticarial such as 1. eruption of wheals, central swelling of various sizes, with or without surrounding erythema; with or without angioedema 2. pruritus or occasional burning sensation 3. skin returning to normal appearance, usually within 1-24 hours Exclusion Criteria: 1. patients who have urticarial for more than 48 hours 2. have severe underlying disease such as heart disease, kidney disease, liver disease 3. pregnancy 4. history of chlorpheniramine maleate, steroid, antihistamines allergy 5. history of antihistamine or steroid uses within 48 hours before ED visit 6. diabetes mellitus 7. suspected of more severe disease or severe allergic reaction 8. patients who don't have pruritus 9. patients who have history of chronic urticaria |
Country | Name | City | State |
---|---|---|---|
Thailand | Chulalongkorn Hospital | Pathum Wan | Bangkok |
Lead Sponsor | Collaborator |
---|---|
Chulalongkorn University |
Thailand,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Itch score | letting the patients mark a cross on a straight line. The end of the left side of a line represents "0 = no itch at all", and the end of the right side of a line represents "10 = the worst itch ever possible". The patients aren't allowed to compare the previous VAS score before doing the cross. | 60 mins | |
Secondary | Chronic urticaria incidence | Chronic urticaria incidence after the use of steroid compare with no steroid use in treatment. | 1 week, 1 month | |
Secondary | Itch score | letting the patients mark a cross on a straight line. The end of the left side of a line represents "0 = no itch at all", and the end of the right side of a line represents "10 = the worst itch ever possible". The patients aren't allowed to compare the previous VAS score before doing the cross. | 0, 15, 30 mins |
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