Impact of Age on the Prevalence of Allergic Sensitization

Allergy Clinical Trial

Official title:

Impact of Age on the Prevalence of Allergic Sensitization

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02730520
• Other study ID #: CHUB-Age-Allergy
• Status: Completed
• Phase: N/A
• First received: April 1, 2016
• Last updated: September 9, 2016
• Start date: May 2016
• Est. completion date: September 2016

Study information

• Verified date: September 2016
• Source: Brugmann University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Belgium: Federal Agency for Medicines and Health Products, FAMHP
• Study type: Observational

Clinical Trial Summary

Worldwide, respiratory diseases have a significant impact on morbidity and mortality of individuals.Tobacco, lifestyle and certain allergens such as dust mites play an important role in the prevalence and morbidity of these diseases. Scientific literature indicates that sensitization to allergens and respiratory diseases (asthma, rhinitis, chronic obstructive pulmonary disease) are closely linked. Moreover, smoking has an effect on allergen sensitivity.

To make a diagnosis of allergic sensitization, skin tests are performed in the patient. One of the methods used is the technique of "prick test". In practice, a drop of purified allergen extract is placed on the patient's skin (arms or back). A little dosis of the product is then injected in the epidermis. If fifteen minutes later, there is an edematous reaction, its diameter is measured in millimeters. From 4 mm, it is considered that the patient is sensitized to the tested foods or allergens.This technique is painless and convenient to patients of all ages, including newborns or conversely very aged patients.

This is a retrospective study based on the encoding and statistical analysis of data collected in patients followed within the Immuno-Allergology Service of the CHU Brugmann Hospital, who received an allergy assessment between 01/01/2015 and 31/12/2015. The allergens tested include: dermatophagoides pteronyssinus (DEPT), dermatophagoides farinae (DPF), blomia, cat, dog, cockroach, orchardgrass, timothy grass, alder, hazel,birch, olive tree, cypress, ash, latex, aspergillus, alternaria, cladosporium, peanut, hazel.

At least 1400 files will be analyzed.

Patients will be distributed in six age groups.The results of the allergen skin tests will be encoded as the edema diameter. The allergenicity score (mean of the skin reactivities for each allergen) will be compared between each age groups. The impact of tabagism, gender, BMI and residential area on the allergic reactivity will also be assessed in the overall population and within each age group.

The main objective is to evaluate the effect of age on the skin test positivity. The secondary objective is to highlight the environmental factors that have an impact on allergic diseases.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1400
• Est. completion date: September 2016
• Est. primary completion date: September 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• All patients followed within the Immuno-Allergology Service of the CHU Brugmann Hospital

• Who received an allergy assessment between 01/01/2015 and 31/12/2015. The allergens tested include: dermatophagoides pteronyssinus (DEPT), dermatophagoides farinae (DPF), blomia, cat, dog, cockroach, orchardgrass, timothy grass, alder, hazel,birch, olive tree, cypress, ash, latex, aspergillus, alternaria, cladosporium, peanut, hazel.

Exclusion Criteria:

• Negative histamine patients

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Allergy

Intervention

Other:
• Retrospective analysis of patient files
The results of the allergen skin tests will be encoded as the edema diameter. The allergenicity score (mean of the skin reactivities for each allergen) will be compared between each age groups. The impact of tabagism, gender, BMI and residential area on the allergic reactivity will also be assessed in the overall population and within each age group.

Locations

Country	Name	City	State
Belgium	CHU Brugmann	Brussels

Sponsors (1)

Lead Sponsor	Collaborator
Brugmann University Hospital

Country where clinical trial is conducted

Belgium, 

References & Publications (1)

Bauchau V, Durham SR. Epidemiological characterization of the intermittent and persistent types of allergic rhinitis. Allergy. 2005 Mar;60(3):350-3. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Allergenicity score	Mean of the skin reactivities for each allergen. The results of the allergen skin tests are encoded as the edema diameter. Scores will be compared between the different age groups.	one year (01/01/2015 to 31/12/2015)	No
Secondary	Smoking status	Effect of the smoking/non smoking status on the allergic reactivity, analysed in the hole group and in the different age groups.	one year (01/01/2015 to 31/12/2015)	No
Secondary	Geographic localisation	Effect of the area of residence on the allergic reactivity, analysed in the hole group and in the different age groups.	one year (01/01/2015 to 31/12/2015)	No
Secondary	Sex	Gender effect on the allergic reactivity, analysed in the hole group and in the different age groups.	one year (01/01/2015 to 31/12/2015)	No
Secondary	Body Mass Index	Effect of the body mass index on the allergic reactivity, analysed in the hole group and in the different age groups.	one year (01/01/2015 to 31/12/2015)	No