Grass Sensitisation and Allergic Rhinitis in Thai Patients

Allergy to Grass Pollen Clinical Trial

Official title:

The Study of Allergens From Grass and Weed Which Are Causes of Allergic Rhinitis in Thai Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01686022
• Other study ID #: NRCT_G04
• Status: Completed
• Phase: N/A
• First received: September 12, 2012
• Last updated: September 13, 2016
• Start date: October 2012
• Est. completion date: October 2015

Study information

• Verified date: September 2016
• Source: Mahidol University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Thailand: Ethical Committee
• Study type: Observational

Clinical Trial Summary

Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.

Description:

To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study.

The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: October 2015
• Est. primary completion date: October 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 10 Years to 50 Years

Eligibility

Inclusion Criteria:

• Allergic rhinitis patients age 10-50 years old

• Control: healthy volunteer age 18-50 years old

Exclusion Criteria:

• Chronic illness such as cardiovascular diseases, liver diseases

• History of anaphylaxis

• Pregnancy

Study Design

N/A

Related Conditions & MeSH terms

• Allergic Rhinitis Due to Weed Pollens
• Allergy to Grass Pollen
• Hypersensitivity
• Rhinitis
• Rhinitis, Allergic

Intervention

Other:
• Immunoblot
serum specific IgE binds to grass extract by immunoblot

Locations

Country	Name	City	State
Thailand	Siriraj Hospital	Bangkoknoi	Bangkok

Sponsors (2)

Lead Sponsor	Collaborator
Mahidol University	National Research Council of Thailand

Country where clinical trial is conducted

Thailand,