Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps

Allergic Rhinitis Clinical Trial

Official title: Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps

Status Recruiting

Clinical Trial Summary

During this project, the investigators want to explore in vitro changes in basal cells and the crosstalk with residing immune cells as potential pathogenic mechanisms in CRSwNP vs healthy controls by using surgically resected patient samples.

Clinical Trial Description

The investigators want to use patient and healthy control samples to study/compare the following aspects in vitro:

1. Investigate differences in epithelial and basal cell functions and differentiation characteristics.

2. Characterize the differences in epithelial cell populations and gene expression patterns. Also include an AR subset, to see if changes are specific for CRSwNP or more general for type 2 inflammatory disease of the upper airways.

3. Investigate basal cell activation via different environmental triggers through TLR stimulation.

4. Look at the genetic imprinting of basal cells before and after being exposed to specific triggers.

5. Investigate whether the secreted proteins from basal cells are chemotactic for other cell populations.

6. Investigate the interaction between basal and regulatory T cells. ;

Related Conditions & MeSH terms

• Allergic Rhinitis
• Chronic Rhinosinusitis With Nasal Polyps
• Nasal Polyps
• Polyps
• Rhinitis
• Rhinitis, Allergic
• Rhinosinusitis
• Sinusitis

• NCT number: NCT06129552
• Study type: Observational [Patient Registry]
• Source: Universitaire Ziekenhuizen KU Leuven
• Contact: Peter Hellings, MD, PhD
• Phone: +32 16 33 23 42
• Email: peter.hellings@uzleuven.be
• Status: Recruiting
• Start date: December 19, 2023
• Completion date: December 2027