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Diphenhydramine and Sweating — BENEXE2022  

Allergic Rhinitis Clinical Trial

Official title:
Does Diphenhydramine Alter Thermoregulatory Responses During Exercise?

Clinical Trial Summary

In 2012, it was estimated that nearly 1 in 4 Canadians suffer from allergic rhinitis. To add, 78% of individuals working in predisposing environments are predicted to develop occupational rhinitis. Currently, the most popular treatment for rhinitis is antihistamine medication such as diphenhydramine, a first-generation antihistamine sold commercially as Benadryl®. Due it its anticholinergic effects, diphenhydramine has been suggested to impair the whole body sweating response during heat stress, potentially leaving consumers at an increased risk of heat-related illness. This randomized control trial approved by Health Canada will investigate whether ingesting extra strength diphenhydramine (50mg) will alter whole-body sweat losses during 60 minutes of exercise.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05586477
Study type Interventional
Source Lakehead University
Contact
Status Completed
Phase Phase 4
Start date November 21, 2022
Completion date June 23, 2023
View Details
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