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Treatment of Allergic Rhinitis and Chronic Polypous Rhinosinusitis With Olfactory Mucosa-derived Mesenchymal Stem Cells

Allergic Rhinitis Clinical Trial

Official title:
Treatment of Patients With Allergic Rhinitis and Chronic Polypous Rhinosinusitis With Olfactory Mucosa-derived Mesenchymal Stem Cells

Clinical Trial Summary

Treatment of patients with allergic rhinitis and chronic polypous rhinosinusitis with olfactory mucosa-derived mesenchymal stem cells

Clinical Trial Description

During the implementation of the project, the methods for the treatment of allergic rhinitis and chronic polypous rhinosinusitis with olfactory mucosa-derived mesenchymal stem cells will be developed. The positive outlook for the effectiveness of MSCs is due to the following: - knowledge of the leading role of immunopathogenetic mechanisms in the development of allergic rhinitis and chronic polypous rhinosinusitis and the pronounced immunomodulating properties of MSCs; - the ability of MSCs to reduce the production of proinflammatory cytokines and suppress immune inflammation; - positive results of preclinical studies of the method of treatment of diseases accompanied by over-activation of the immune system, including autoimmune diseases, in animals and the first clinical studies in patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05167552
Study type Interventional
Source Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Contact Natalia Antonevich, Dr
Phone +375173691763
Email antonevich.n@gmail.com
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date March 1, 2022
Completion date December 31, 2023
View Details
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