Allergic Rhinitis Clinical Trial
Official title:
Efficacy and Safety of Birch Pollen Immunotherapy in Local Allergic Rhinitis
Local allergic rhinitis (LAR) is relatively new disease. The question of effect of allergen specific immunotherapy on LAR is open. The randomized, double blind placebo controlled trial of birch subcutaneous AIT on LAR were performed in twenty eight patients. The therapy was performed during 24 months in proportion 15 patients with AIT and 13 placebo. The primary endpoint was decreased of symptoms medication score (SMS). Additionally monitoring serum specific IgE, specific IgG4 and nasal specific IgE (nsIgE) to Bet v1 and parameters of safety and quality of life were provided.
Local allergic rhinitis (LAR) is still an under diagnosed and under treated disease. It is
characterised by local production of IgE during natural exposure to aeroallergens. These
patients have negative skin prick tests and serum-specific IgEs but have positive nasal
provocation tests for aeroallergens. More than 50% of patients with chronic non-allergic
rhinitis may have a problem with lack of LAR diagnosis. Misdiagnosis can lead to mistakes in
the treatment as well as inefficiencies.
Besides on only local IgE-mediated reaction, allergen immunotherapy (AIT) could be a
potential way of treatment such patients. However, there are only sufficient data that the
AIT is effective in allergic rhinoconjunctivitis and asthma to pollens and house dust mites
and some animal.
The aim of this study was to assess the safety and efficacy of AIT for birch pollen
allergens in patients with local allergic rhinitis and a confirmed birch pollen allergy.
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