Epidemiology of Pecan Nut Allergy

Allergic Reaction Clinical Trial

— PEC-ALL  

Official title:

Retrospective Study on Pecan Nut Allergy Epidemiology

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05185362
• Other study ID #: RECHMPL21_0726
• Status: Recruiting
• Start date: November 1, 2021
• Est. completion date: April 1, 2022

Study information

• Verified date: December 2021
• Source: University Hospital, Montpellier
• Contact: Davide CAIMMI, MD
• Phone: 467336112
• Email: davide.caimmi[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

IgE-mediated food allergy can manifest with reactions ranging from hives to anaphylactic shock. The diagnosis is based on the confirmation of sensitization to the food allergen by skin tests (prick) and the determination of specific IgE directed against the food source and molecular allergens. The gold standard remains the oral provocation test, which is performed in a hospital environment. Once the diagnosis is made, an elimination diet is still considered as the cornerstone of treatment for most food allergies.

While some allergies, such as cow's milk or egg, tend to resolve spontaneously, others, such as allergy to pecan nuts, show a tendency to be persistent. In addition, pecan allergy is often characterized by potentially serious clinical reactions, compared to other foods, which can even be life threatening. In our clinical practice, the investigators found that patients with allergies to pecan nuts often present with severe hypersensitivity reactions when challenged orally to this food. Beyond this information, there are few studies regarding pecans. The investigators decided to retrospectively evaluate the results of oral food challenge and of the allergy work-up in our patients sensitized and allergic to pecan nuts, to better understand the current epidemiology of such food allergy.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: April 1, 2022
• Est. primary completion date: January 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 5 Years to 70 Years

Eligibility

Inclusion criteria:

• Patients assessed for pecan allergy, through oral food challenge, from January 2000 to december 2021, at the University Hospital of Montpellier

• Patients with a positive skin prick test and/or positive specific IgE to pecan nut

Exclusion criteria:

• Patients not affiliated to French Social Security

• Patients not capable of understanding French

• Patients sensitized to pecan nut, who did not perform an oral food challenge to this food allergen

Related Conditions & MeSH terms

• Allergic Reaction
• Hypersensitivity
• Nut Hypersensitivity

Locations

Country	Name	City	State
France	Uhmontpellier	Montpellier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence of challenge-proven pecan allergy	Prevalence of challenge-proven pecan allergy in sensitized patients	day 1
Secondary	Epidemiological characteristics of pecan allergic patient	Epidemiological characteristics of pecan allergic patient(cypress pollen-induced allergic rhinitis or food allergy to peach)	day 1
Secondary	cut-off of specific IgE	cut-off of specific IgE and of results of prick test to predict pecan allergy in sensitized and allergic patients	day 1